Educational information, not medical advice.See how evidence is graded

Tired all the time, no energy

You sleep, but you wake up tired. By noon you feel flat and heavy. Coffee helps for an hour, then it fades.

This kind of tiredness is not laziness. It is a sign your body is working harder than it should. Many things can cause it, and one of them is extra fat stored in the liver.

Doctors call that fatty liver, or NAFLD. Low energy is often the first thing people notice.

Some feel a dull ache under the right ribs. Many feel nothing else at all.

When to see someone

Go to the emergency room now if your skin or eyes turn yellow. Go now if you vomit blood, or if your stool is black and tarry. Go now if you have bad belly pain with fever.

Call your doctor the same day if your urine turns dark brown. Same day if your belly swells fast, or both legs swell. Same day if you feel faint or your heart races when you stand.

Book a visit within a week if the tiredness has lasted more than two weeks. Book a visit if you bruise with no cause, or bleed from small cuts for a long time. Book a visit if you lose weight without trying.

Ask for a sleep test if you snore loudly or gasp in your sleep. Ask for an iron test if you have heavy periods. Ask for help right away if you feel hopeless or think of harming yourself.

Why it happens

Your liver helps turn food into fuel. It also stores sugar and clears waste from the blood. When fat builds up inside it, the liver does this work less well.

Fatty liver often comes with high blood sugar and high blood fats. Your cells stop taking in sugar the way they should. So the fuel is in your blood, but not where your muscles need it.

A fatty liver can also be mildly swollen. Your body runs a low, steady clean-up response. That drains energy, even while you sit still.

What else it could be

The same tired feeling comes from many causes. Guessing wrong means you treat the wrong thing. Here is how they differ.

Low iron (anemia) makes you pale, short of breath on stairs, and cold. Your heart may race when you stand up. It is common in women with heavy periods.

A slow thyroid brings weight gain, dry skin, constipation, and cold hands. Hair may thin. This tiredness feels slow and foggy, not sleepy.

Sleep apnea makes you snore, gasp, or wake with a dry mouth and headache. You sleep eight hours and still feel wrecked. A partner often notices before you do.

Depression takes away interest, not just energy. Food and hobbies stop feeling good. Mornings are often the worst part of the day.

High blood sugar or diabetes brings thirst, more trips to the bathroom, and blurry sight. It often sits next to fatty liver, not instead of it.

Low vitamin B12 or low vitamin D can do it too. So can many drugs, such as blood pressure pills, antihistamines, and some antidepressants. Check the label of anything new you started.

A recent virus can leave you drained for weeks. Fatty liver tends to be quieter. It shows up on a blood test or scan, often by chance.

How to read the grades below

The options below come from our page on Non-Alcoholic Fatty Liver Disease (NAFLD). Each one carries two labels.

The first label is the evidence grade. A means strong trials in people, B means smaller or mixed studies, and C means early or limited findings. D means lab work only, and “insufficient” means the research cannot settle it yet.

The second label is the traditional tier. T3 means long use in more than one tradition, T2 means long use in one, and T1 means known use. T0 means no such record.

These grades come from research on Non-Alcoholic Fatty Liver Disease (NAFLD), the parent Health Topic, not on tired all the time no energy.

A grade tells you how strong the research is, not how well something will work for you. Talk to a doctor or pharmacist before you start anything, above all if you take other medicines.

What to try first

Get blood tests first. Ask for liver enzymes, blood sugar or HbA1c, iron, thyroid, and B12. This tells you which path to take.

While you wait, work on the basics. Walk 30 minutes most days.

Cut sugary drinks and fruit juice. Losing even 5 out of every 100 pounds can lower liver fat.

Some options have strong trial support. Omega-3 fatty acids (evidence grade A, traditional tier T0) can lower fat in the liver.

Berberine (evidence grade A, traditional tier T0) may help blood sugar and liver fat. Fasting (evidence grade A, traditional tier T3) is backed by trials and by long folk use.

Intermittent Fasting (evidence grade insufficient, traditional tier T0) is a looser, newer term.

The proof for it is thin so far. Do not fast at all if you are pregnant, under 18, or take insulin. Ask your doctor first.

Two options have fair support. Chicory (Persian Kasni) (evidence grade B, traditional tier T3) is both a folk herb and a study herb. TUDCA (evidence grade B, traditional tier T0) is a bile salt studied for liver health.

Two have weak support. Probiotics (Lactobacillus plantarum P8) (evidence grade C, traditional tier T0) target the gut.

Shilajit (evidence grade C, traditional tier T3) is a folk tar used in Ayurveda. Early results only.

Four more are used a lot, but the proof is thin. Milk Thistle (Silybum marianum) (evidence grade insufficient, traditional tier T2) is mostly folk use. Turmeric (evidence grade insufficient, traditional tier T3) is also mostly folk use.

Vitamin E (evidence grade insufficient, traditional tier T0) and Phosphatidylcholine (evidence grade insufficient, traditional tier T0) have not been proven here.

Tell your doctor about any supplement you take. Some clash with drugs. Berberine and blood sugar pills are one example.

How long it takes

Sleep and food changes can lift your mood in one or two weeks. Energy often moves before any test does.

Liver fat shifts more slowly. Studies that show change usually run 8 to 24 weeks. Blood tests are often redone at 3 or 6 months.

If you feel no better after 6 weeks of real effort, go back to your doctor. Another cause may be driving it. Nothing here is a sure thing, and results differ from person to person.

Non-Alcoholic Fatty Liver Disease (NAFLD): natural remedies and the evidence behind them

15 options · 3 graded B · 5 graded C · 7 traditional or ungraded

How do I most want to support my liver day to day?

I want targeted nutrients and supplements aimed at lowering liver fat, protecting liver cells, and fixing gaps

  1. Omega-3 fatty acids

    Supported by smaller clinical studies· Recognised traditional use (Evidence grade B · Traditional use recognised)Recognised traditional use

    Nutrient studied for lowering liver fat

    Why it may be relevant
    If you want a targeted, research-backed nutrient, omega-3s (EPA/DHA) are a mainstream option studied for reducing liver fat and triglycerides.
    Why try it
    EPA and DHA are incorporated into cell membranes and support anti-inflammatory pathways and healthy triglyceride levels, both relevant to fatty liver.
    Dose or use
    Marine EPA/DHA supplements are usually taken with a meal; choose a reputable fish oil or algae-based product and follow its directions.
    Time to results
    Typically 8–12 weeks
    Key study
    Meta-analysis (2025, PMID 40441053): Omega-3 polyunsaturated fatty acids and nonalcoholic fatty liver disease in adults: A meta-analysis of randomized controlled trials. Pooling 20 RCTs (1,615 adults), omega-3s improved ultrasound-measured hepatic steatosis and GGT, though liver fat measured by MRI was not significantly changed and some publication bias was noted.
    Caution
    High doses can thin the blood; check with your practitioner if you take anticoagulants or are due for surgery.
  2. Vitamin E

    Supported by smaller clinical studies· Recognised traditional use (Evidence grade B · Traditional use recognised)Recognised traditional use

    Antioxidant vitamin studied in fatty liver

    Why it may be relevant
    If you want a targeted, research-backed nutrient, vitamin E is an antioxidant that has been studied in people with fatty liver.
    Why try it
    As a fat-soluble antioxidant it helps neutralise the oxidative stress that contributes to liver-cell damage.
    Dose or use
    Trials in fatty liver used natural-source vitamin E around 800 IU/day, taken with a fat-containing meal. Use a reputable product under practitioner guidance, avoid stacking multiple high-dose sources, and do not self-prescribe long-term high doses.
    Time to results
    Typically 12+ weeks
    Key study
    Randomized controlled trial (2010, PMID 20427778): Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis (the PIVENS trial). In 247 adults with biopsy-proven NASH without diabetes, vitamin E 800 IU/day for 96 weeks significantly improved liver histology versus placebo. The strongest evidence is in NASH — the inflammatory form of NAFLD — rather than simple fatty liver.
    Caution
    High doses can increase bleeding risk and may not suit everyone; discuss with your practitioner before starting, especially if you take blood thinners.
  3. Vitamin D Deficiency

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Common, checkable gap linked to liver health

    Why it may be relevant
    If you want to find and fix nutrient gaps, vitamin D is a simple blood test and low levels are repeatedly associated with fatty liver.
    Why try it
    Correcting a confirmed deficiency is a defensible, low-risk step that supports immune and metabolic health tied to the liver.
    Dose or use
    Ask your clinician for a 25-hydroxy vitamin D blood test, then supplement to the dose they recommend based on your result.
    Time to results
    Typically 8–12 weeks to restore levels
    Key study
    Low vitamin D is associated with NAFLD in observational research; this is a deficiency to check and correct, not a proven treatment.
    Caution
    Vitamin D is fat-soluble and can build up; supplement to correct a measured deficiency rather than mega-dosing blindly.
  4. TUDCA

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Bile-acid derivative for liver support

    Why it may be relevant
    If you want a targeted supplement aimed at liver cells, TUDCA is a bile-acid derivative whose profile centres specifically on liver health.
    Why try it
    TUDCA has cytoprotective, anti-apoptotic properties that help protect liver cells and support bile flow.
    Dose or use
    Available as capsules taken with water; follow a reputable product's directions and introduce it gradually.
    Time to results
    Typically 8–12 weeks
    Key study
    Studied for cholestatic and fatty liver conditions; a specific controlled NAFLD trial is not cited here for this recommendation.
    Caution
    May cause mild digestive upset or diarrhea; consult a practitioner before use if you have gallbladder or bile-duct conditions or take other medications.
  5. Phosphatidylcholine

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Phospholipid support for liver cells

    Why it may be relevant
    If you're after nutrients that protect liver cells, phosphatidylcholine is a phospholipid that helps repair and maintain cell membranes.
    Why try it
    As an essential phospholipid, it supports the structure and function of liver-cell membranes and healthy fat handling.
    Dose or use
    Taken as capsules or granules with food; follow a reputable product's directions.
    Time to results
    Typically 8–12 weeks
    Key study
    Used as a liver-membrane support supplement; a specific controlled NAFLD trial is not cited here for this recommendation.
    Caution
    May cause mild digestive upset, sweating, or nausea at higher doses; check with a practitioner if you take other medications.

I want to change when I eat — fasting windows and meal timing to give my liver a break

  1. Intermittent Fasting

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Timed eating may improve liver markers

    Why it may be relevant
    If you're using meal timing as your main lever, intermittent fasting has been studied in NAFLD patients, with reviews suggesting it may help.
    Why try it
    Cycling periods of eating and fasting may help reduce liver fat, improve lipid profiles, and support healthy body weight.
    Dose or use
    A common approach is 16/8 time-restricted eating (fast 16 hours, eat within an 8-hour window), or the 5:2 pattern. Start gradually and work with a practitioner, especially if you take diabetes or blood-pressure medications.
    Time to results
    Typically 8–12 weeks
    Key study
    Systematic review (2024, PMID 38321893): Effect of Intermittent Fasting on Lipid Profile, Anthropometric and Hepatic Markers in Non-Alcoholic Fatty Liver Disease (NAFLD). Reported outcomes are surrogate markers (lipids, body measures, liver markers), not long-term clinical endpoints.
    Caution
    Not suitable during pregnancy, for those with a history of disordered eating, or without medical guidance if on diabetes medications.
  2. Fasting

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Religious-calendar fasting studied in NAFLD

    Why it may be relevant
    If a defined, calendar-based eating schedule fits your routine better than daily time-restriction, structured fasting has been looked at specifically in NAFLD patients.
    Why try it
    Longer daily fasting windows and periodic caloric restriction can lower liver fat and improve hepatic markers, though findings in this setting are mixed.
    Dose or use
    Think dawn-to-dusk (Ramadan-style) fasting or alternate-day / periodic caloric restriction rather than daily 16/8. Keep hydrated during eating windows and check with a practitioner before starting, especially if you take medications.
    Time to results
    Typically 4–12 weeks
    Key study
    Systematic review (2023, PMID 38303901): The impacts of Ramadan fasting for patients with non-alcoholic fatty liver disease (NAFLD): a systematic review. Evidence in this setting is mixed.
    Caution
    Always consult a healthcare practitioner before starting any fasting protocol, especially with existing health conditions or medications.

I want to work through my gut — supporting the gut-liver axis with probiotics and metabolic balance

  1. Berberine

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · Traditional use recognised)Recognised traditional use

    Traditionally used to support gut and metabolic health

    Why it may be relevant
    For those targeting gut and metabolic health, berberine has been studied in small human trials in NAFLD — mainly for its effect on blood sugar — and is traditionally used to support metabolic balance relevant to liver fat.
    Why try it
    In early randomized trials berberine improved fasting blood sugar, and it is traditionally used to support healthy lipid levels and gut flora — all tied to liver fat metabolism. Liver-specific benefits are still mostly from animal studies.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Systematic review and meta-analysis (2025, PMID 40949129): Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment. Only 4 human RCTs were included; berberine significantly improved fasting blood glucose, while liver-specific benefits (ALT/AST, lipids) came mainly from animal studies, so human evidence is early and better trials are needed.
    Caution
    May interact with diabetes and blood pressure medications; not recommended during pregnancy or breastfeeding.
  2. Probiotics (Lactobacillus plantarum P8)

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Gut-support strain, unconfirmed for NAFLD

    Why it may be relevant
    If you want to work on your liver through your gut, this is a well-characterised probiotic strain for general gut health — though its specific benefit for NAFLD has not been shown for this exact strain.
    Why try it
    The gut-liver axis links microbiome health to liver inflammation, and supporting gut flora is a reasonable, low-risk lever to explore.
    Dose or use
    Take as directed on a reputable probiotic product; consistency over several weeks matters more than dose. Consult a practitioner if you are immunocompromised.
    Time to results
    Typically 8–12 weeks
    Key study
    Studied for general gut health; this specific strain has not been confirmed for NAFLD in controlled clinical trials. (Broader probiotic trials in NAFLD used mixed or unspecified strains.)
    Caution
    Generally well tolerated; those who are immunocompromised or seriously ill should consult a doctor before use.

I'd rather lean on classic liver herbs like milk thistle and turmeric with deep traditional roots

  1. Chicory (Persian Kasni)

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Clinically studied for lipids and obesity in NAFLD

    Why it may be relevant
    For those drawn to herbal options, chicory seed has been studied alongside turmeric in a clinical trial showing benefits on lipid profile and obesity markers in NAFLD.
    Why try it
    Chicory contains compounds that may support bile flow, healthy cholesterol levels, and liver fat reduction.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2019, PMID 31017556): Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD).
    Caution
    May cause digestive upset in some; use with caution if allergic to plants in the daisy family.
  2. Milk Thistle

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Classic liver-support herb (silymarin)

    Why it may be relevant
    If you lean toward herbal remedies, milk thistle is the best-known botanical for liver support and a natural fit alongside turmeric and chicory.
    Why try it
    Its active complex, silymarin, has antioxidant and anti-inflammatory properties and has been tested in randomized trials for fatty liver, where it showed modest improvements in liver enzymes.
    Dose or use
    Standardised silymarin extracts are typically taken with food; follow a reputable product's directions and start at the lower end.
    Time to results
    Typically 8–12 weeks
    Key study
    Cochrane systematic review (2025, PMID 40552569): Silymarin for adults with metabolic dysfunction-associated steatotic liver disease. Across randomized trials silymarin showed some improvement in liver enzymes, but the certainty of the evidence was low and benefits on liver histology or long-term outcomes remain unproven.
    Caution
    May cause mild digestive upset; use caution if you are allergic to plants in the daisy/ragweed family, and check for interactions if on medications.
  3. Turmeric

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Traditionally used to support liver and digestion

    Why it may be relevant
    For those interested in traditional herbal remedies, turmeric has a long history of use for liver and digestive health.
    Why try it
    Its active compound curcumin has antioxidant properties and, in concentrated supplement form, has been studied in randomized trials for fatty liver, where it modestly lowered liver enzymes.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    GRADE-assessed meta-analysis (2025, PMID 38213188): Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease. Across 15 RCTs (905 participants), curcumin modestly lowered liver enzymes (ALT/AST). The evidence is for concentrated curcumin supplements rather than culinary turmeric and rests on liver-enzyme markers rather than liver histology.
    Caution
    High doses may interact with blood thinners; use cautiously if you have gallbladder disease.
  4. Shilajit

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Traditionally used as a restorative liver tonic

    Why it may be relevant
    For those interested in traditional remedies, shilajit has been used in Ayurvedic practice as a general tonic with traditional applications for liver support.
    Why try it
    Traditionally used to support energy, detoxification pathways, and overall organ vitality in Ayurvedic medicine.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Quality and purity vary widely; choose purified forms only and consult a practitioner if on medications or with kidney concerns.

I'd like gentle hands-on self-care — acupressure points traditionally used for liver support

  1. GB34 (Yanglingquan) - Gallbladder 34

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Liver-gallbladder acupressure point

    Why it may be relevant
    If you're exploring acupressure, GB34 is the classic liver-and-gallbladder point and pairs naturally with LV3.
    Why try it
    Traditionally used to support liver and gallbladder function and ease liver-related tension and digestive discomfort.
    Dose or use
    Find it on the outer lower leg, just below and in front of the head of the fibula; apply firm circular pressure for 1–2 minutes per side.
    Time to results
    Varies; used as ongoing supportive self-care
    Key study
    Traditionally used in TCM for liver and gallbladder support; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid pressing on broken or irritated skin; acupressure is complementary and does not replace medical care for your liver.
  2. LV3 (Taichong)

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Primary Liver-meridian acupressure point

    Why it may be relevant
    If you're open to acupressure, LV3 sits on the Liver meridian and is the classic point TCM uses for liver support.
    Why try it
    Traditionally used to regulate the flow of qi and ease liver-related tension and stress; a gentle self-care practice you can do at home.
    Dose or use
    Find it on the top of the foot, in the hollow between the first and second toes; apply firm circular pressure for 1–2 minutes per foot.
    Time to results
    Varies; used as ongoing supportive self-care
    Key study
    Traditionally used in TCM for liver support; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid pressing on broken or irritated skin; acupressure supports wellbeing but does not replace medical care for your liver.

When choosing what to try first, what matters most to you?

I want simple, low-effort additions — a daily capsule, a quick blood test, or a two-minute self-care ritual

  1. Omega-3 fatty acids

    Supported by smaller clinical studies· Recognised traditional use (Evidence grade B · Traditional use recognised)Recognised traditional use

    Nutrient studied for lowering liver fat

    Why it may be relevant
    If you want a targeted, research-backed nutrient, omega-3s (EPA/DHA) are a mainstream option studied for reducing liver fat and triglycerides.
    Why try it
    EPA and DHA are incorporated into cell membranes and support anti-inflammatory pathways and healthy triglyceride levels, both relevant to fatty liver.
    Dose or use
    Marine EPA/DHA supplements are usually taken with a meal; choose a reputable fish oil or algae-based product and follow its directions.
    Time to results
    Typically 8–12 weeks
    Key study
    Meta-analysis (2025, PMID 40441053): Omega-3 polyunsaturated fatty acids and nonalcoholic fatty liver disease in adults: A meta-analysis of randomized controlled trials. Pooling 20 RCTs (1,615 adults), omega-3s improved ultrasound-measured hepatic steatosis and GGT, though liver fat measured by MRI was not significantly changed and some publication bias was noted.
    Caution
    High doses can thin the blood; check with your practitioner if you take anticoagulants or are due for surgery.
  2. Vitamin D Deficiency

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Common, checkable gap linked to liver health

    Why it may be relevant
    If you want to find and fix nutrient gaps, vitamin D is a simple blood test and low levels are repeatedly associated with fatty liver.
    Why try it
    Correcting a confirmed deficiency is a defensible, low-risk step that supports immune and metabolic health tied to the liver.
    Dose or use
    Ask your clinician for a 25-hydroxy vitamin D blood test, then supplement to the dose they recommend based on your result.
    Time to results
    Typically 8–12 weeks to restore levels
    Key study
    Low vitamin D is associated with NAFLD in observational research; this is a deficiency to check and correct, not a proven treatment.
    Caution
    Vitamin D is fat-soluble and can build up; supplement to correct a measured deficiency rather than mega-dosing blindly.
  3. TUDCA

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Bile-acid derivative for liver support

    Why it may be relevant
    If you want a targeted supplement aimed at liver cells, TUDCA is a bile-acid derivative whose profile centres specifically on liver health.
    Why try it
    TUDCA has cytoprotective, anti-apoptotic properties that help protect liver cells and support bile flow.
    Dose or use
    Available as capsules taken with water; follow a reputable product's directions and introduce it gradually.
    Time to results
    Typically 8–12 weeks
    Key study
    Studied for cholestatic and fatty liver conditions; a specific controlled NAFLD trial is not cited here for this recommendation.
    Caution
    May cause mild digestive upset or diarrhea; consult a practitioner before use if you have gallbladder or bile-duct conditions or take other medications.
  4. Phosphatidylcholine

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Phospholipid support for liver cells

    Why it may be relevant
    If you're after nutrients that protect liver cells, phosphatidylcholine is a phospholipid that helps repair and maintain cell membranes.
    Why try it
    As an essential phospholipid, it supports the structure and function of liver-cell membranes and healthy fat handling.
    Dose or use
    Taken as capsules or granules with food; follow a reputable product's directions.
    Time to results
    Typically 8–12 weeks
    Key study
    Used as a liver-membrane support supplement; a specific controlled NAFLD trial is not cited here for this recommendation.
    Caution
    May cause mild digestive upset, sweating, or nausea at higher doses; check with a practitioner if you take other medications.
  5. GB34 (Yanglingquan) - Gallbladder 34

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Liver-gallbladder acupressure point

    Why it may be relevant
    If you're exploring acupressure, GB34 is the classic liver-and-gallbladder point and pairs naturally with LV3.
    Why try it
    Traditionally used to support liver and gallbladder function and ease liver-related tension and digestive discomfort.
    Dose or use
    Find it on the outer lower leg, just below and in front of the head of the fibula; apply firm circular pressure for 1–2 minutes per side.
    Time to results
    Varies; used as ongoing supportive self-care
    Key study
    Traditionally used in TCM for liver and gallbladder support; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid pressing on broken or irritated skin; acupressure is complementary and does not replace medical care for your liver.
  6. LV3 (Taichong)

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Primary Liver-meridian acupressure point

    Why it may be relevant
    If you're open to acupressure, LV3 sits on the Liver meridian and is the classic point TCM uses for liver support.
    Why try it
    Traditionally used to regulate the flow of qi and ease liver-related tension and stress; a gentle self-care practice you can do at home.
    Dose or use
    Find it on the top of the foot, in the hollow between the first and second toes; apply firm circular pressure for 1–2 minutes per foot.
    Time to results
    Varies; used as ongoing supportive self-care
    Key study
    Traditionally used in TCM for liver support; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid pressing on broken or irritated skin; acupressure supports wellbeing but does not replace medical care for your liver.
  7. Probiotics (Lactobacillus plantarum P8)

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Gut-support strain, unconfirmed for NAFLD

    Why it may be relevant
    If you want to work on your liver through your gut, this is a well-characterised probiotic strain for general gut health — though its specific benefit for NAFLD has not been shown for this exact strain.
    Why try it
    The gut-liver axis links microbiome health to liver inflammation, and supporting gut flora is a reasonable, low-risk lever to explore.
    Dose or use
    Take as directed on a reputable probiotic product; consistency over several weeks matters more than dose. Consult a practitioner if you are immunocompromised.
    Time to results
    Typically 8–12 weeks
    Key study
    Studied for general gut health; this specific strain has not been confirmed for NAFLD in controlled clinical trials. (Broader probiotic trials in NAFLD used mixed or unspecified strains.)
    Caution
    Generally well tolerated; those who are immunocompromised or seriously ill should consult a doctor before use.

I want to start with the options that have the most human research behind them for fatty liver

  1. Intermittent Fasting

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Timed eating may improve liver markers

    Why it may be relevant
    If you're using meal timing as your main lever, intermittent fasting has been studied in NAFLD patients, with reviews suggesting it may help.
    Why try it
    Cycling periods of eating and fasting may help reduce liver fat, improve lipid profiles, and support healthy body weight.
    Dose or use
    A common approach is 16/8 time-restricted eating (fast 16 hours, eat within an 8-hour window), or the 5:2 pattern. Start gradually and work with a practitioner, especially if you take diabetes or blood-pressure medications.
    Time to results
    Typically 8–12 weeks
    Key study
    Systematic review (2024, PMID 38321893): Effect of Intermittent Fasting on Lipid Profile, Anthropometric and Hepatic Markers in Non-Alcoholic Fatty Liver Disease (NAFLD). Reported outcomes are surrogate markers (lipids, body measures, liver markers), not long-term clinical endpoints.
    Caution
    Not suitable during pregnancy, for those with a history of disordered eating, or without medical guidance if on diabetes medications.
  2. Omega-3 fatty acids

    Supported by smaller clinical studies· Recognised traditional use (Evidence grade B · Traditional use recognised)Recognised traditional use

    Nutrient studied for lowering liver fat

    Why it may be relevant
    If you want a targeted, research-backed nutrient, omega-3s (EPA/DHA) are a mainstream option studied for reducing liver fat and triglycerides.
    Why try it
    EPA and DHA are incorporated into cell membranes and support anti-inflammatory pathways and healthy triglyceride levels, both relevant to fatty liver.
    Dose or use
    Marine EPA/DHA supplements are usually taken with a meal; choose a reputable fish oil or algae-based product and follow its directions.
    Time to results
    Typically 8–12 weeks
    Key study
    Meta-analysis (2025, PMID 40441053): Omega-3 polyunsaturated fatty acids and nonalcoholic fatty liver disease in adults: A meta-analysis of randomized controlled trials. Pooling 20 RCTs (1,615 adults), omega-3s improved ultrasound-measured hepatic steatosis and GGT, though liver fat measured by MRI was not significantly changed and some publication bias was noted.
    Caution
    High doses can thin the blood; check with your practitioner if you take anticoagulants or are due for surgery.
  3. Vitamin E

    Supported by smaller clinical studies· Recognised traditional use (Evidence grade B · Traditional use recognised)Recognised traditional use

    Antioxidant vitamin studied in fatty liver

    Why it may be relevant
    If you want a targeted, research-backed nutrient, vitamin E is an antioxidant that has been studied in people with fatty liver.
    Why try it
    As a fat-soluble antioxidant it helps neutralise the oxidative stress that contributes to liver-cell damage.
    Dose or use
    Trials in fatty liver used natural-source vitamin E around 800 IU/day, taken with a fat-containing meal. Use a reputable product under practitioner guidance, avoid stacking multiple high-dose sources, and do not self-prescribe long-term high doses.
    Time to results
    Typically 12+ weeks
    Key study
    Randomized controlled trial (2010, PMID 20427778): Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis (the PIVENS trial). In 247 adults with biopsy-proven NASH without diabetes, vitamin E 800 IU/day for 96 weeks significantly improved liver histology versus placebo. The strongest evidence is in NASH — the inflammatory form of NAFLD — rather than simple fatty liver.
    Caution
    High doses can increase bleeding risk and may not suit everyone; discuss with your practitioner before starting, especially if you take blood thinners.
  4. Chicory (Persian Kasni)

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Clinically studied for lipids and obesity in NAFLD

    Why it may be relevant
    For those drawn to herbal options, chicory seed has been studied alongside turmeric in a clinical trial showing benefits on lipid profile and obesity markers in NAFLD.
    Why try it
    Chicory contains compounds that may support bile flow, healthy cholesterol levels, and liver fat reduction.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2019, PMID 31017556): Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD).
    Caution
    May cause digestive upset in some; use with caution if allergic to plants in the daisy family.
  5. Milk Thistle

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Classic liver-support herb (silymarin)

    Why it may be relevant
    If you lean toward herbal remedies, milk thistle is the best-known botanical for liver support and a natural fit alongside turmeric and chicory.
    Why try it
    Its active complex, silymarin, has antioxidant and anti-inflammatory properties and has been tested in randomized trials for fatty liver, where it showed modest improvements in liver enzymes.
    Dose or use
    Standardised silymarin extracts are typically taken with food; follow a reputable product's directions and start at the lower end.
    Time to results
    Typically 8–12 weeks
    Key study
    Cochrane systematic review (2025, PMID 40552569): Silymarin for adults with metabolic dysfunction-associated steatotic liver disease. Across randomized trials silymarin showed some improvement in liver enzymes, but the certainty of the evidence was low and benefits on liver histology or long-term outcomes remain unproven.
    Caution
    May cause mild digestive upset; use caution if you are allergic to plants in the daisy/ragweed family, and check for interactions if on medications.
  6. Turmeric

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Traditionally used to support liver and digestion

    Why it may be relevant
    For those interested in traditional herbal remedies, turmeric has a long history of use for liver and digestive health.
    Why try it
    Its active compound curcumin has antioxidant properties and, in concentrated supplement form, has been studied in randomized trials for fatty liver, where it modestly lowered liver enzymes.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    GRADE-assessed meta-analysis (2025, PMID 38213188): Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease. Across 15 RCTs (905 participants), curcumin modestly lowered liver enzymes (ALT/AST). The evidence is for concentrated curcumin supplements rather than culinary turmeric and rests on liver-enzyme markers rather than liver histology.
    Caution
    High doses may interact with blood thinners; use cautiously if you have gallbladder disease.

I'm ready to commit to a bigger routine change, like restructuring when and how I eat

  1. Intermittent Fasting

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Timed eating may improve liver markers

    Why it may be relevant
    If you're using meal timing as your main lever, intermittent fasting has been studied in NAFLD patients, with reviews suggesting it may help.
    Why try it
    Cycling periods of eating and fasting may help reduce liver fat, improve lipid profiles, and support healthy body weight.
    Dose or use
    A common approach is 16/8 time-restricted eating (fast 16 hours, eat within an 8-hour window), or the 5:2 pattern. Start gradually and work with a practitioner, especially if you take diabetes or blood-pressure medications.
    Time to results
    Typically 8–12 weeks
    Key study
    Systematic review (2024, PMID 38321893): Effect of Intermittent Fasting on Lipid Profile, Anthropometric and Hepatic Markers in Non-Alcoholic Fatty Liver Disease (NAFLD). Reported outcomes are surrogate markers (lipids, body measures, liver markers), not long-term clinical endpoints.
    Caution
    Not suitable during pregnancy, for those with a history of disordered eating, or without medical guidance if on diabetes medications.
  2. Fasting

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Religious-calendar fasting studied in NAFLD

    Why it may be relevant
    If a defined, calendar-based eating schedule fits your routine better than daily time-restriction, structured fasting has been looked at specifically in NAFLD patients.
    Why try it
    Longer daily fasting windows and periodic caloric restriction can lower liver fat and improve hepatic markers, though findings in this setting are mixed.
    Dose or use
    Think dawn-to-dusk (Ramadan-style) fasting or alternate-day / periodic caloric restriction rather than daily 16/8. Keep hydrated during eating windows and check with a practitioner before starting, especially if you take medications.
    Time to results
    Typically 4–12 weeks
    Key study
    Systematic review (2023, PMID 38303901): The impacts of Ramadan fasting for patients with non-alcoholic fatty liver disease (NAFLD): a systematic review. Evidence in this setting is mixed.
    Caution
    Always consult a healthcare practitioner before starting any fasting protocol, especially with existing health conditions or medications.
  3. Berberine

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · Traditional use recognised)Recognised traditional use

    Traditionally used to support gut and metabolic health

    Why it may be relevant
    For those targeting gut and metabolic health, berberine has been studied in small human trials in NAFLD — mainly for its effect on blood sugar — and is traditionally used to support metabolic balance relevant to liver fat.
    Why try it
    In early randomized trials berberine improved fasting blood sugar, and it is traditionally used to support healthy lipid levels and gut flora — all tied to liver fat metabolism. Liver-specific benefits are still mostly from animal studies.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Systematic review and meta-analysis (2025, PMID 40949129): Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment. Only 4 human RCTs were included; berberine significantly improved fasting blood glucose, while liver-specific benefits (ALT/AST, lipids) came mainly from animal studies, so human evidence is early and better trials are needed.
    Caution
    May interact with diabetes and blood pressure medications; not recommended during pregnancy or breastfeeding.

I'm drawn to remedies with a long traditional history, even if modern trials are still catching up

  1. Milk Thistle

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Classic liver-support herb (silymarin)

    Why it may be relevant
    If you lean toward herbal remedies, milk thistle is the best-known botanical for liver support and a natural fit alongside turmeric and chicory.
    Why try it
    Its active complex, silymarin, has antioxidant and anti-inflammatory properties and has been tested in randomized trials for fatty liver, where it showed modest improvements in liver enzymes.
    Dose or use
    Standardised silymarin extracts are typically taken with food; follow a reputable product's directions and start at the lower end.
    Time to results
    Typically 8–12 weeks
    Key study
    Cochrane systematic review (2025, PMID 40552569): Silymarin for adults with metabolic dysfunction-associated steatotic liver disease. Across randomized trials silymarin showed some improvement in liver enzymes, but the certainty of the evidence was low and benefits on liver histology or long-term outcomes remain unproven.
    Caution
    May cause mild digestive upset; use caution if you are allergic to plants in the daisy/ragweed family, and check for interactions if on medications.
  2. Berberine

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · Traditional use recognised)Recognised traditional use

    Traditionally used to support gut and metabolic health

    Why it may be relevant
    For those targeting gut and metabolic health, berberine has been studied in small human trials in NAFLD — mainly for its effect on blood sugar — and is traditionally used to support metabolic balance relevant to liver fat.
    Why try it
    In early randomized trials berberine improved fasting blood sugar, and it is traditionally used to support healthy lipid levels and gut flora — all tied to liver fat metabolism. Liver-specific benefits are still mostly from animal studies.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Systematic review and meta-analysis (2025, PMID 40949129): Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment. Only 4 human RCTs were included; berberine significantly improved fasting blood glucose, while liver-specific benefits (ALT/AST, lipids) came mainly from animal studies, so human evidence is early and better trials are needed.
    Caution
    May interact with diabetes and blood pressure medications; not recommended during pregnancy or breastfeeding.
  3. Turmeric

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Traditionally used to support liver and digestion

    Why it may be relevant
    For those interested in traditional herbal remedies, turmeric has a long history of use for liver and digestive health.
    Why try it
    Its active compound curcumin has antioxidant properties and, in concentrated supplement form, has been studied in randomized trials for fatty liver, where it modestly lowered liver enzymes.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    GRADE-assessed meta-analysis (2025, PMID 38213188): Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease. Across 15 RCTs (905 participants), curcumin modestly lowered liver enzymes (ALT/AST). The evidence is for concentrated curcumin supplements rather than culinary turmeric and rests on liver-enzyme markers rather than liver histology.
    Caution
    High doses may interact with blood thinners; use cautiously if you have gallbladder disease.
  4. GB34 (Yanglingquan) - Gallbladder 34

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Liver-gallbladder acupressure point

    Why it may be relevant
    If you're exploring acupressure, GB34 is the classic liver-and-gallbladder point and pairs naturally with LV3.
    Why try it
    Traditionally used to support liver and gallbladder function and ease liver-related tension and digestive discomfort.
    Dose or use
    Find it on the outer lower leg, just below and in front of the head of the fibula; apply firm circular pressure for 1–2 minutes per side.
    Time to results
    Varies; used as ongoing supportive self-care
    Key study
    Traditionally used in TCM for liver and gallbladder support; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid pressing on broken or irritated skin; acupressure is complementary and does not replace medical care for your liver.
  5. LV3 (Taichong)

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Primary Liver-meridian acupressure point

    Why it may be relevant
    If you're open to acupressure, LV3 sits on the Liver meridian and is the classic point TCM uses for liver support.
    Why try it
    Traditionally used to regulate the flow of qi and ease liver-related tension and stress; a gentle self-care practice you can do at home.
    Dose or use
    Find it on the top of the foot, in the hollow between the first and second toes; apply firm circular pressure for 1–2 minutes per foot.
    Time to results
    Varies; used as ongoing supportive self-care
    Key study
    Traditionally used in TCM for liver support; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid pressing on broken or irritated skin; acupressure supports wellbeing but does not replace medical care for your liver.
  6. Shilajit

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Traditionally used as a restorative liver tonic

    Why it may be relevant
    For those interested in traditional remedies, shilajit has been used in Ayurvedic practice as a general tonic with traditional applications for liver support.
    Why try it
    Traditionally used to support energy, detoxification pathways, and overall organ vitality in Ayurvedic medicine.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Quality and purity vary widely; choose purified forms only and consult a practitioner if on medications or with kidney concerns.

Evidence grades describe the strength of published research for Non-Alcoholic Fatty Liver Disease (NAFLD), not a promise of results. Nothing here is medical advice — talk to your clinician before starting anything, especially alongside prescription medication.

Questions people ask

Can a fatty liver really make me this tired?

Yes, low energy is the most common thing people report with fatty liver. The liver helps handle sugar and fat, so the work gets harder when fat builds up inside it.

But tiredness alone does not prove it. A blood test and a scan are the way to find out.

What tests should I ask my doctor for?

Ask for liver enzymes, called ALT and AST. Ask for blood sugar or HbA1c, plus cholesterol.

Also ask for a full blood count, iron, thyroid, and vitamin B12, since those cause the same tired feeling. If liver enzymes are high, your doctor may order an ultrasound scan.

Why am I still tired after eight hours of sleep?

Sleep time and sleep quality are not the same thing. Sleep apnea breaks your sleep many times an hour, and you may not recall it.

Snoring, gasping, a dry mouth, or a morning headache are clues. Ask your doctor about a sleep test.

Does fatty liver hurt?

Most people feel no pain at all. Some feel a dull ache or full feeling under the right ribs.

Sharp pain is not typical and needs a check. Bad belly pain with fever or yellow skin means go to the emergency room.

Will losing weight fix it?

Weight loss is the best studied step for fatty liver. Losing about 5 out of every 100 pounds can lower liver fat, and more loss tends to help more.

Slow, steady loss works better than a crash diet. No step works for every person, so keep your doctor in the loop.

Is milk thistle worth taking?

Milk Thistle (Silybum marianum) has an evidence grade of insufficient and a traditional tier of T2. That means people have used it for a long time, but the trials do not yet show a clear result.

It is not a reason to skip diet and walking. Tell your doctor if you take it, since it can affect other drugs.

Can I still drink alcohol?

Alcohol adds work for a liver that is already loaded with fat. Even if your fatty liver is not caused by drink, cutting back is wise.

Ask your doctor what limit fits your case. If your liver tests are high, many doctors say to stop for a while.

Is fatty liver something I can reverse?

In many people, liver fat does go down when weight, sugar, and food change. Early fatty liver responds better than scarred liver.

No one can promise what will happen in your case. Regular blood tests show if you are moving the right way.

Other ways people describe this

Same underlying problem, different words.

These suggestions come from our full page on Non-Alcoholic Fatty Liver Disease (NAFLD), where you can see every option and how it is graded. Evidence grades are explained in our methodology, and every phrasing we cover is listed under health topics.

Remedies people try for this

Remedies recommended for the same conditions. Evidence grades are shown on each page.

See your options in the app

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Reviewed by the HealisticMD editorial team How we grade evidence →