Non-Alcoholic Fatty Liver Disease (NAFLD): natural remedies and the evidence behind them
Non-Alcoholic Fatty Liver Disease (NAFLD) is a buildup of excess fat in the liver not caused by alcohol, which can lead to inflammation and scarring over…
15 options3 graded B5 graded C7 traditional or ungraded
B
Guided condition explorer
Start with what sounds familiar.
Choose what sounds familiar, then choose the kind of support you want to explore. HealisticMD narrows the library without presenting the result as personal medical advice.
If you want a targeted, research-backed nutrient, omega-3s (EPA/DHA) are a mainstream option studied for reducing liver fat and triglycerides.
EPA and DHA are incorporated into cell membranes and support anti-inflammatory pathways and healthy triglyceride levels, both relevant to fatty liver.
Dose or use Marine EPA/DHA supplements are usually taken with a meal; choose a reputable fish oil or algae-based product and follow its directions.
Key study Meta-analysis (2025, PMID 40441053): Omega-3 polyunsaturated fatty acids and nonalcoholic fatty liver disease in adults: A meta-analysis of randomized controlled trials. Pooling 20 RCTs (1,615 adults), omega-3s improved ultrasound-measured hepatic steatosis and GGT, though liver fat measured by MRI was not significantly changed and some publication bias was noted.
EvidenceSupported by smaller clinical studies · Recognised traditional useTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: High doses can thin the blood; check with your practitioner if you take anticoagulants or are due for surgery.
If you want a targeted, research-backed nutrient, vitamin E is an antioxidant that has been studied in people with fatty liver.
As a fat-soluble antioxidant it helps neutralise the oxidative stress that contributes to liver-cell damage.
Dose or use Trials in fatty liver used natural-source vitamin E around 800 IU/day, taken with a fat-containing meal. Use a reputable product under practitioner guidance, avoid stacking multiple high-dose sources, and do not self-prescribe long-term high doses.
Key study Randomized controlled trial (2010, PMID 20427778): Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis (the PIVENS trial). In 247 adults with biopsy-proven NASH without diabetes, vitamin E 800 IU/day for 96 weeks significantly improved liver histology versus placebo. The strongest evidence is in NASH — the inflammatory form of NAFLD — rather than simple fatty liver.
EvidenceSupported by smaller clinical studies · Recognised traditional useTime to resultsTypically 12+ weeksTraditional useRecognised traditional use
Caution: High doses can increase bleeding risk and may not suit everyone; discuss with your practitioner before starting, especially if you take blood thinners.
Evidence grade not assigned · Traditional use recognised
Phospholipid support for liver cells
Why it may be relevant
If you're after nutrients that protect liver cells, phosphatidylcholine is a phospholipid that helps repair and maintain cell membranes.
As an essential phospholipid, it supports the structure and function of liver-cell membranes and healthy fat handling.
Dose or use Taken as capsules or granules with food; follow a reputable product's directions.
Key study Used as a liver-membrane support supplement; a specific controlled NAFLD trial is not cited here for this recommendation.
EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: May cause mild digestive upset, sweating, or nausea at higher doses; check with a practitioner if you take other medications.
Evidence grade not assigned · Traditional use recognised
Bile-acid derivative for liver support
Why it may be relevant
If you want a targeted supplement aimed at liver cells, TUDCA is a bile-acid derivative whose profile centres specifically on liver health.
TUDCA has cytoprotective, anti-apoptotic properties that help protect liver cells and support bile flow.
Dose or use Available as capsules taken with water; follow a reputable product's directions and introduce it gradually.
Key study Studied for cholestatic and fatty liver conditions; a specific controlled NAFLD trial is not cited here for this recommendation.
EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: May cause mild digestive upset or diarrhea; consult a practitioner before use if you have gallbladder or bile-duct conditions or take other medications.
Evidence grade not assigned · Traditional use recognised
Common, checkable gap linked to liver health
Why it may be relevant
If you want to find and fix nutrient gaps, vitamin D is a simple blood test and low levels are repeatedly associated with fatty liver.
Correcting a confirmed deficiency is a defensible, low-risk step that supports immune and metabolic health tied to the liver.
Dose or use Ask your clinician for a 25-hydroxy vitamin D blood test, then supplement to the dose they recommend based on your result.
Key study Low vitamin D is associated with NAFLD in observational research; this is a deficiency to check and correct, not a proven treatment.
EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 8–12 weeks to restore levelsTraditional useRecognised traditional use
Caution: Vitamin D is fat-soluble and can build up; supplement to correct a measured deficiency rather than mega-dosing blindly.
How do I most want to support my liver day to day?
I want to change when I eat — fasting windows and meal timing to give my liver a break
If you're using meal timing as your main lever, intermittent fasting has been studied in NAFLD patients, with reviews suggesting it may help.
Cycling periods of eating and fasting may help reduce liver fat, improve lipid profiles, and support healthy body weight.
Dose or use A common approach is 16/8 time-restricted eating (fast 16 hours, eat within an 8-hour window), or the 5:2 pattern. Start gradually and work with a practitioner, especially if you take diabetes or blood-pressure medications.
Key study Systematic review (2024, PMID 38321893): Effect of Intermittent Fasting on Lipid Profile, Anthropometric and Hepatic Markers in Non-Alcoholic Fatty Liver Disease (NAFLD). Reported outcomes are surrogate markers (lipids, body measures, liver markers), not long-term clinical endpoints.
EvidenceSupported by smaller clinical studiesTime to resultsTypically 8–12 weeks
Caution: Not suitable during pregnancy, for those with a history of disordered eating, or without medical guidance if on diabetes medications.
If a defined, calendar-based eating schedule fits your routine better than daily time-restriction, structured fasting has been looked at specifically in NAFLD patients.
Longer daily fasting windows and periodic caloric restriction can lower liver fat and improve hepatic markers, though findings in this setting are mixed.
Dose or use Think dawn-to-dusk (Ramadan-style) fasting or alternate-day / periodic caloric restriction rather than daily 16/8. Keep hydrated during eating windows and check with a practitioner before starting, especially if you take medications.
Key study Systematic review (2023, PMID 38303901): The impacts of Ramadan fasting for patients with non-alcoholic fatty liver disease (NAFLD): a systematic review. Evidence in this setting is mixed.
EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 4–12 weeks
Caution: Always consult a healthcare practitioner before starting any fasting protocol, especially with existing health conditions or medications.
If you want a targeted, research-backed nutrient, omega-3s (EPA/DHA) are a mainstream option studied for reducing liver fat and triglycerides.
EPA and DHA are incorporated into cell membranes and support anti-inflammatory pathways and healthy triglyceride levels, both relevant to fatty liver.
Dose or use Marine EPA/DHA supplements are usually taken with a meal; choose a reputable fish oil or algae-based product and follow its directions.
Key study Meta-analysis (2025, PMID 40441053): Omega-3 polyunsaturated fatty acids and nonalcoholic fatty liver disease in adults: A meta-analysis of randomized controlled trials. Pooling 20 RCTs (1,615 adults), omega-3s improved ultrasound-measured hepatic steatosis and GGT, though liver fat measured by MRI was not significantly changed and some publication bias was noted.
EvidenceSupported by smaller clinical studies · Recognised traditional useTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: High doses can thin the blood; check with your practitioner if you take anticoagulants or are due for surgery.
Evidence grade not assigned · Traditional use long-standing
Liver-gallbladder acupressure point
Why it may be relevant
If you're exploring acupressure, GB34 is the classic liver-and-gallbladder point and pairs naturally with LV3.
Traditionally used to support liver and gallbladder function and ease liver-related tension and digestive discomfort.
Dose or use Find it on the outer lower leg, just below and in front of the head of the fibula; apply firm circular pressure for 1–2 minutes per side.
Key study Traditionally used in TCM for liver and gallbladder support; this specific use has not been confirmed in controlled clinical trials.
EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsVaries; used as ongoing supportive self-careTraditional useLong-standing traditional staple
Caution: Avoid pressing on broken or irritated skin; acupressure is complementary and does not replace medical care for your liver.
–
Pressure point
LV3 (Taichong)
Evidence grade not assigned · Traditional use long-standing
Primary Liver-meridian acupressure point
Why it may be relevant
If you're open to acupressure, LV3 sits on the Liver meridian and is the classic point TCM uses for liver support.
Traditionally used to regulate the flow of qi and ease liver-related tension and stress; a gentle self-care practice you can do at home.
Dose or use Find it on the top of the foot, in the hollow between the first and second toes; apply firm circular pressure for 1–2 minutes per foot.
Key study Traditionally used in TCM for liver support; this specific use has not been confirmed in controlled clinical trials.
EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsVaries; used as ongoing supportive self-careTraditional useLong-standing traditional staple
Caution: Avoid pressing on broken or irritated skin; acupressure supports wellbeing but does not replace medical care for your liver.
Evidence grade not assigned · Traditional use recognised
Phospholipid support for liver cells
Why it may be relevant
If you're after nutrients that protect liver cells, phosphatidylcholine is a phospholipid that helps repair and maintain cell membranes.
As an essential phospholipid, it supports the structure and function of liver-cell membranes and healthy fat handling.
Dose or use Taken as capsules or granules with food; follow a reputable product's directions.
Key study Used as a liver-membrane support supplement; a specific controlled NAFLD trial is not cited here for this recommendation.
EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: May cause mild digestive upset, sweating, or nausea at higher doses; check with a practitioner if you take other medications.
Evidence grade not assigned · Traditional use recognised
Gut-support strain, unconfirmed for NAFLD
Why it may be relevant
If you want to work on your liver through your gut, this is a well-characterised probiotic strain for general gut health — though its specific benefit for NAFLD has not been shown for this exact strain.
The gut-liver axis links microbiome health to liver inflammation, and supporting gut flora is a reasonable, low-risk lever to explore.
Dose or use Take as directed on a reputable probiotic product; consistency over several weeks matters more than dose. Consult a practitioner if you are immunocompromised.
Key study Studied for general gut health; this specific strain has not been confirmed for NAFLD in controlled clinical trials. (Broader probiotic trials in NAFLD used mixed or unspecified strains.)
EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: Generally well tolerated; those who are immunocompromised or seriously ill should consult a doctor before use.
Evidence grade not assigned · Traditional use recognised
Bile-acid derivative for liver support
Why it may be relevant
If you want a targeted supplement aimed at liver cells, TUDCA is a bile-acid derivative whose profile centres specifically on liver health.
TUDCA has cytoprotective, anti-apoptotic properties that help protect liver cells and support bile flow.
Dose or use Available as capsules taken with water; follow a reputable product's directions and introduce it gradually.
Key study Studied for cholestatic and fatty liver conditions; a specific controlled NAFLD trial is not cited here for this recommendation.
EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: May cause mild digestive upset or diarrhea; consult a practitioner before use if you have gallbladder or bile-duct conditions or take other medications.
Evidence grade not assigned · Traditional use recognised
Common, checkable gap linked to liver health
Why it may be relevant
If you want to find and fix nutrient gaps, vitamin D is a simple blood test and low levels are repeatedly associated with fatty liver.
Correcting a confirmed deficiency is a defensible, low-risk step that supports immune and metabolic health tied to the liver.
Dose or use Ask your clinician for a 25-hydroxy vitamin D blood test, then supplement to the dose they recommend based on your result.
Key study Low vitamin D is associated with NAFLD in observational research; this is a deficiency to check and correct, not a proven treatment.
EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 8–12 weeks to restore levelsTraditional useRecognised traditional use
Caution: Vitamin D is fat-soluble and can build up; supplement to correct a measured deficiency rather than mega-dosing blindly.
When choosing what to try first, what matters most to you?
I want to start with the options that have the most human research behind them for fatty liver
If you're using meal timing as your main lever, intermittent fasting has been studied in NAFLD patients, with reviews suggesting it may help.
Cycling periods of eating and fasting may help reduce liver fat, improve lipid profiles, and support healthy body weight.
Dose or use A common approach is 16/8 time-restricted eating (fast 16 hours, eat within an 8-hour window), or the 5:2 pattern. Start gradually and work with a practitioner, especially if you take diabetes or blood-pressure medications.
Key study Systematic review (2024, PMID 38321893): Effect of Intermittent Fasting on Lipid Profile, Anthropometric and Hepatic Markers in Non-Alcoholic Fatty Liver Disease (NAFLD). Reported outcomes are surrogate markers (lipids, body measures, liver markers), not long-term clinical endpoints.
EvidenceSupported by smaller clinical studiesTime to resultsTypically 8–12 weeks
Caution: Not suitable during pregnancy, for those with a history of disordered eating, or without medical guidance if on diabetes medications.
If you want a targeted, research-backed nutrient, omega-3s (EPA/DHA) are a mainstream option studied for reducing liver fat and triglycerides.
EPA and DHA are incorporated into cell membranes and support anti-inflammatory pathways and healthy triglyceride levels, both relevant to fatty liver.
Dose or use Marine EPA/DHA supplements are usually taken with a meal; choose a reputable fish oil or algae-based product and follow its directions.
Key study Meta-analysis (2025, PMID 40441053): Omega-3 polyunsaturated fatty acids and nonalcoholic fatty liver disease in adults: A meta-analysis of randomized controlled trials. Pooling 20 RCTs (1,615 adults), omega-3s improved ultrasound-measured hepatic steatosis and GGT, though liver fat measured by MRI was not significantly changed and some publication bias was noted.
EvidenceSupported by smaller clinical studies · Recognised traditional useTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: High doses can thin the blood; check with your practitioner if you take anticoagulants or are due for surgery.
If you want a targeted, research-backed nutrient, vitamin E is an antioxidant that has been studied in people with fatty liver.
As a fat-soluble antioxidant it helps neutralise the oxidative stress that contributes to liver-cell damage.
Dose or use Trials in fatty liver used natural-source vitamin E around 800 IU/day, taken with a fat-containing meal. Use a reputable product under practitioner guidance, avoid stacking multiple high-dose sources, and do not self-prescribe long-term high doses.
Key study Randomized controlled trial (2010, PMID 20427778): Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis (the PIVENS trial). In 247 adults with biopsy-proven NASH without diabetes, vitamin E 800 IU/day for 96 weeks significantly improved liver histology versus placebo. The strongest evidence is in NASH — the inflammatory form of NAFLD — rather than simple fatty liver.
EvidenceSupported by smaller clinical studies · Recognised traditional useTime to resultsTypically 12+ weeksTraditional useRecognised traditional use
Caution: High doses can increase bleeding risk and may not suit everyone; discuss with your practitioner before starting, especially if you take blood thinners.
Clinically studied for lipids and obesity in NAFLD
Why it may be relevant
For those drawn to herbal options, chicory seed has been studied alongside turmeric in a clinical trial showing benefits on lipid profile and obesity markers in NAFLD.
Chicory contains compounds that may support bile flow, healthy cholesterol levels, and liver fat reduction.
Dose or use Follow product labeling; consult a healthcare practitioner.
Key study RCT (2019, PMID 31017556): Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD).
EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 8–12 weeks
Caution: May cause digestive upset in some; use with caution if allergic to plants in the daisy family.
If you lean toward herbal remedies, milk thistle is the best-known botanical for liver support and a natural fit alongside turmeric and chicory.
Its active complex, silymarin, has antioxidant and anti-inflammatory properties and has been tested in randomized trials for fatty liver, where it showed modest improvements in liver enzymes.
Dose or use Standardised silymarin extracts are typically taken with food; follow a reputable product's directions and start at the lower end.
Key study Cochrane systematic review (2025, PMID 40552569): Silymarin for adults with metabolic dysfunction-associated steatotic liver disease. Across randomized trials silymarin showed some improvement in liver enzymes, but the certainty of the evidence was low and benefits on liver histology or long-term outcomes remain unproven.
EvidenceCenturies of traditional use · Limited human trials so farTime to resultsTypically 8–12 weeksTraditional useLong-standing traditional staple
Caution: May cause mild digestive upset; use caution if you are allergic to plants in the daisy/ragweed family, and check for interactions if on medications.
For those interested in traditional herbal remedies, turmeric has a long history of use for liver and digestive health.
Its active compound curcumin has antioxidant properties and, in concentrated supplement form, has been studied in randomized trials for fatty liver, where it modestly lowered liver enzymes.
Dose or use Follow product labeling; consult a healthcare practitioner.
Key study GRADE-assessed meta-analysis (2025, PMID 38213188): Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease. Across 15 RCTs (905 participants), curcumin modestly lowered liver enzymes (ALT/AST). The evidence is for concentrated curcumin supplements rather than culinary turmeric and rests on liver-enzyme markers rather than liver histology.
EvidenceCenturies of traditional use · Limited human trials so farTime to resultsTypically 8–12 weeksTraditional useLong-standing traditional staple
Caution: High doses may interact with blood thinners; use cautiously if you have gallbladder disease.
If you're using meal timing as your main lever, intermittent fasting has been studied in NAFLD patients, with reviews suggesting it may help.
Cycling periods of eating and fasting may help reduce liver fat, improve lipid profiles, and support healthy body weight.
Dose or use A common approach is 16/8 time-restricted eating (fast 16 hours, eat within an 8-hour window), or the 5:2 pattern. Start gradually and work with a practitioner, especially if you take diabetes or blood-pressure medications.
Key study Systematic review (2024, PMID 38321893): Effect of Intermittent Fasting on Lipid Profile, Anthropometric and Hepatic Markers in Non-Alcoholic Fatty Liver Disease (NAFLD). Reported outcomes are surrogate markers (lipids, body measures, liver markers), not long-term clinical endpoints.
EvidenceSupported by smaller clinical studiesTime to resultsTypically 8–12 weeks
Caution: Not suitable during pregnancy, for those with a history of disordered eating, or without medical guidance if on diabetes medications.
Traditionally used to support gut and metabolic health
Why it may be relevant
For those targeting gut and metabolic health, berberine has been studied in small human trials in NAFLD — mainly for its effect on blood sugar — and is traditionally used to support metabolic balance relevant to liver fat.
In early randomized trials berberine improved fasting blood sugar, and it is traditionally used to support healthy lipid levels and gut flora — all tied to liver fat metabolism. Liver-specific benefits are still mostly from animal studies.
Dose or use Follow product labeling; consult a healthcare practitioner.
Key study Systematic review and meta-analysis (2025, PMID 40949129): Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment. Only 4 human RCTs were included; berberine significantly improved fasting blood glucose, while liver-specific benefits (ALT/AST, lipids) came mainly from animal studies, so human evidence is early and better trials are needed.
EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: May interact with diabetes and blood pressure medications; not recommended during pregnancy or breastfeeding.
If a defined, calendar-based eating schedule fits your routine better than daily time-restriction, structured fasting has been looked at specifically in NAFLD patients.
Longer daily fasting windows and periodic caloric restriction can lower liver fat and improve hepatic markers, though findings in this setting are mixed.
Dose or use Think dawn-to-dusk (Ramadan-style) fasting or alternate-day / periodic caloric restriction rather than daily 16/8. Keep hydrated during eating windows and check with a practitioner before starting, especially if you take medications.
Key study Systematic review (2023, PMID 38303901): The impacts of Ramadan fasting for patients with non-alcoholic fatty liver disease (NAFLD): a systematic review. Evidence in this setting is mixed.
EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 4–12 weeks
Caution: Always consult a healthcare practitioner before starting any fasting protocol, especially with existing health conditions or medications.
Traditionally used to support gut and metabolic health
Why it may be relevant
For those targeting gut and metabolic health, berberine has been studied in small human trials in NAFLD — mainly for its effect on blood sugar — and is traditionally used to support metabolic balance relevant to liver fat.
In early randomized trials berberine improved fasting blood sugar, and it is traditionally used to support healthy lipid levels and gut flora — all tied to liver fat metabolism. Liver-specific benefits are still mostly from animal studies.
Dose or use Follow product labeling; consult a healthcare practitioner.
Key study Systematic review and meta-analysis (2025, PMID 40949129): Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment. Only 4 human RCTs were included; berberine significantly improved fasting blood glucose, while liver-specific benefits (ALT/AST, lipids) came mainly from animal studies, so human evidence is early and better trials are needed.
EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: May interact with diabetes and blood pressure medications; not recommended during pregnancy or breastfeeding.
Evidence grade not assigned · Traditional use recognised
Gut-support strain, unconfirmed for NAFLD
Why it may be relevant
If you want to work on your liver through your gut, this is a well-characterised probiotic strain for general gut health — though its specific benefit for NAFLD has not been shown for this exact strain.
The gut-liver axis links microbiome health to liver inflammation, and supporting gut flora is a reasonable, low-risk lever to explore.
Dose or use Take as directed on a reputable probiotic product; consistency over several weeks matters more than dose. Consult a practitioner if you are immunocompromised.
Key study Studied for general gut health; this specific strain has not been confirmed for NAFLD in controlled clinical trials. (Broader probiotic trials in NAFLD used mixed or unspecified strains.)
EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: Generally well tolerated; those who are immunocompromised or seriously ill should consult a doctor before use.
Clinically studied for lipids and obesity in NAFLD
Why it may be relevant
For those drawn to herbal options, chicory seed has been studied alongside turmeric in a clinical trial showing benefits on lipid profile and obesity markers in NAFLD.
Chicory contains compounds that may support bile flow, healthy cholesterol levels, and liver fat reduction.
Dose or use Follow product labeling; consult a healthcare practitioner.
Key study RCT (2019, PMID 31017556): Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD).
EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 8–12 weeks
Caution: May cause digestive upset in some; use with caution if allergic to plants in the daisy family.
If you lean toward herbal remedies, milk thistle is the best-known botanical for liver support and a natural fit alongside turmeric and chicory.
Its active complex, silymarin, has antioxidant and anti-inflammatory properties and has been tested in randomized trials for fatty liver, where it showed modest improvements in liver enzymes.
Dose or use Standardised silymarin extracts are typically taken with food; follow a reputable product's directions and start at the lower end.
Key study Cochrane systematic review (2025, PMID 40552569): Silymarin for adults with metabolic dysfunction-associated steatotic liver disease. Across randomized trials silymarin showed some improvement in liver enzymes, but the certainty of the evidence was low and benefits on liver histology or long-term outcomes remain unproven.
EvidenceCenturies of traditional use · Limited human trials so farTime to resultsTypically 8–12 weeksTraditional useLong-standing traditional staple
Caution: May cause mild digestive upset; use caution if you are allergic to plants in the daisy/ragweed family, and check for interactions if on medications.
For those interested in traditional herbal remedies, turmeric has a long history of use for liver and digestive health.
Its active compound curcumin has antioxidant properties and, in concentrated supplement form, has been studied in randomized trials for fatty liver, where it modestly lowered liver enzymes.
Dose or use Follow product labeling; consult a healthcare practitioner.
Key study GRADE-assessed meta-analysis (2025, PMID 38213188): Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease. Across 15 RCTs (905 participants), curcumin modestly lowered liver enzymes (ALT/AST). The evidence is for concentrated curcumin supplements rather than culinary turmeric and rests on liver-enzyme markers rather than liver histology.
EvidenceCenturies of traditional use · Limited human trials so farTime to resultsTypically 8–12 weeksTraditional useLong-standing traditional staple
Caution: High doses may interact with blood thinners; use cautiously if you have gallbladder disease.
Evidence grade not assigned · Traditional use recognised
Traditionally used as a restorative liver tonic
Why it may be relevant
For those interested in traditional remedies, shilajit has been used in Ayurvedic practice as a general tonic with traditional applications for liver support.
Traditionally used to support energy, detoxification pathways, and overall organ vitality in Ayurvedic medicine.
Dose or use Follow product labeling; consult a healthcare practitioner.
Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.
EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: Quality and purity vary widely; choose purified forms only and consult a practitioner if on medications or with kidney concerns.
Traditionally used to support gut and metabolic health
Why it may be relevant
For those targeting gut and metabolic health, berberine has been studied in small human trials in NAFLD — mainly for its effect on blood sugar — and is traditionally used to support metabolic balance relevant to liver fat.
In early randomized trials berberine improved fasting blood sugar, and it is traditionally used to support healthy lipid levels and gut flora — all tied to liver fat metabolism. Liver-specific benefits are still mostly from animal studies.
Dose or use Follow product labeling; consult a healthcare practitioner.
Key study Systematic review and meta-analysis (2025, PMID 40949129): Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment. Only 4 human RCTs were included; berberine significantly improved fasting blood glucose, while liver-specific benefits (ALT/AST, lipids) came mainly from animal studies, so human evidence is early and better trials are needed.
EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: May interact with diabetes and blood pressure medications; not recommended during pregnancy or breastfeeding.
If you lean toward herbal remedies, milk thistle is the best-known botanical for liver support and a natural fit alongside turmeric and chicory.
Its active complex, silymarin, has antioxidant and anti-inflammatory properties and has been tested in randomized trials for fatty liver, where it showed modest improvements in liver enzymes.
Dose or use Standardised silymarin extracts are typically taken with food; follow a reputable product's directions and start at the lower end.
Key study Cochrane systematic review (2025, PMID 40552569): Silymarin for adults with metabolic dysfunction-associated steatotic liver disease. Across randomized trials silymarin showed some improvement in liver enzymes, but the certainty of the evidence was low and benefits on liver histology or long-term outcomes remain unproven.
EvidenceCenturies of traditional use · Limited human trials so farTime to resultsTypically 8–12 weeksTraditional useLong-standing traditional staple
Caution: May cause mild digestive upset; use caution if you are allergic to plants in the daisy/ragweed family, and check for interactions if on medications.
For those interested in traditional herbal remedies, turmeric has a long history of use for liver and digestive health.
Its active compound curcumin has antioxidant properties and, in concentrated supplement form, has been studied in randomized trials for fatty liver, where it modestly lowered liver enzymes.
Dose or use Follow product labeling; consult a healthcare practitioner.
Key study GRADE-assessed meta-analysis (2025, PMID 38213188): Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease. Across 15 RCTs (905 participants), curcumin modestly lowered liver enzymes (ALT/AST). The evidence is for concentrated curcumin supplements rather than culinary turmeric and rests on liver-enzyme markers rather than liver histology.
EvidenceCenturies of traditional use · Limited human trials so farTime to resultsTypically 8–12 weeksTraditional useLong-standing traditional staple
Caution: High doses may interact with blood thinners; use cautiously if you have gallbladder disease.
Evidence grade not assigned · Traditional use long-standing
Liver-gallbladder acupressure point
Why it may be relevant
If you're exploring acupressure, GB34 is the classic liver-and-gallbladder point and pairs naturally with LV3.
Traditionally used to support liver and gallbladder function and ease liver-related tension and digestive discomfort.
Dose or use Find it on the outer lower leg, just below and in front of the head of the fibula; apply firm circular pressure for 1–2 minutes per side.
Key study Traditionally used in TCM for liver and gallbladder support; this specific use has not been confirmed in controlled clinical trials.
EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsVaries; used as ongoing supportive self-careTraditional useLong-standing traditional staple
Caution: Avoid pressing on broken or irritated skin; acupressure is complementary and does not replace medical care for your liver.
–
Pressure point
LV3 (Taichong)
Evidence grade not assigned · Traditional use long-standing
Primary Liver-meridian acupressure point
Why it may be relevant
If you're open to acupressure, LV3 sits on the Liver meridian and is the classic point TCM uses for liver support.
Traditionally used to regulate the flow of qi and ease liver-related tension and stress; a gentle self-care practice you can do at home.
Dose or use Find it on the top of the foot, in the hollow between the first and second toes; apply firm circular pressure for 1–2 minutes per foot.
Key study Traditionally used in TCM for liver support; this specific use has not been confirmed in controlled clinical trials.
EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsVaries; used as ongoing supportive self-careTraditional useLong-standing traditional staple
Caution: Avoid pressing on broken or irritated skin; acupressure supports wellbeing but does not replace medical care for your liver.
Evidence grade not assigned · Traditional use recognised
Traditionally used as a restorative liver tonic
Why it may be relevant
For those interested in traditional remedies, shilajit has been used in Ayurvedic practice as a general tonic with traditional applications for liver support.
Traditionally used to support energy, detoxification pathways, and overall organ vitality in Ayurvedic medicine.
Dose or use Follow product labeling; consult a healthcare practitioner.
Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.
EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 8–12 weeksTraditional useRecognised traditional use
Caution: Quality and purity vary widely; choose purified forms only and consult a practitioner if on medications or with kidney concerns.
How do I most want to support my liver day to day?
I'd like gentle hands-on self-care — acupressure points traditionally used for liver support
–
Pressure point
GB34 (Yanglingquan) - Gallbladder 34
Evidence grade not assigned · Traditional use long-standing
Liver-gallbladder acupressure point
Why it may be relevant
If you're exploring acupressure, GB34 is the classic liver-and-gallbladder point and pairs naturally with LV3.
Traditionally used to support liver and gallbladder function and ease liver-related tension and digestive discomfort.
Dose or use Find it on the outer lower leg, just below and in front of the head of the fibula; apply firm circular pressure for 1–2 minutes per side.
Key study Traditionally used in TCM for liver and gallbladder support; this specific use has not been confirmed in controlled clinical trials.
EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsVaries; used as ongoing supportive self-careTraditional useLong-standing traditional staple
Caution: Avoid pressing on broken or irritated skin; acupressure is complementary and does not replace medical care for your liver.
–
Pressure point
LV3 (Taichong)
Evidence grade not assigned · Traditional use long-standing
Primary Liver-meridian acupressure point
Why it may be relevant
If you're open to acupressure, LV3 sits on the Liver meridian and is the classic point TCM uses for liver support.
Traditionally used to regulate the flow of qi and ease liver-related tension and stress; a gentle self-care practice you can do at home.
Dose or use Find it on the top of the foot, in the hollow between the first and second toes; apply firm circular pressure for 1–2 minutes per foot.
Key study Traditionally used in TCM for liver support; this specific use has not been confirmed in controlled clinical trials.
EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsVaries; used as ongoing supportive self-careTraditional useLong-standing traditional staple
Caution: Avoid pressing on broken or irritated skin; acupressure supports wellbeing but does not replace medical care for your liver.
Evidence grades describe the strength of published research for Non-Alcoholic Fatty Liver Disease (NAFLD), not a promise of results. A higher grade is not a personal recommendation. Nothing here is medical advice — talk to your clinician before starting anything, especially alongside prescription medication.
Related pressure points
Hands-on options you can try yourself.
Acupressure is a comfort measure, not a treatment for Non-Alcoholic Fatty Liver Disease (NAFLD) itself. Each page shows where the point is and how to press it.
The evidence behind Non-Alcoholic Fatty Liver Disease (NAFLD), in one page
We track 13 natural options for Non-Alcoholic Fatty Liver Disease (NAFLD) — what each is typically used for, usual dose, cautions, and the study behind the ones with real trial data.
One email with the summary. We'll also send a short weekly evidence update — unsubscribe any time.
Build your plan in the app
Build and track your natural-health plan for Non-Alcoholic Fatty Liver Disease (NAFLD) in the app.
