What is Bojungikgi-tang (Supplement Middle)?

Bojungikgi-tang is a foundational multi-herb formula from East Asian medicine, originally formulated by the Chinese physician Li Dongyuan in the 13th century and later adopted into Korean Hanbang and Japanese Kampo traditions. It combines ten synergistic herbs — led by Astragalus and Ginseng — to restore what practitioners call 'middle burner qi,' meaning the digestive and metabolic energy centered in the spleen and stomach. It is one of the most widely studied classical formulas in modern East Asian pharmacological research.

How does Bojungikgi-tang (Supplement Middle) work?

From a modern science perspective, the formula works through several overlapping pathways: its lead herbs Astragalus and Ginseng modulate immune cell activity, help regulate cortisol and stress hormones, and support mitochondrial energy production. Bupleurum and Cimicifuga have anti-inflammatory effects and are thought to support smooth muscle tone, which is why the formula has traditionally been used for prolapse conditions. Licorice and Atractylodes support gut motility and mucosal integrity, improving nutrient absorption over time.

What forms does Bojungikgi-tang (Supplement Middle) come in?

Traditional preparation is as a decoction — simmered raw herbs taken as a warm tea two to three times daily. Modern forms include standardized granules (most common in clinical use), capsules, tablets, and pre-made liquid sachets. Granule and decoction forms are generally considered the most potent. Capsule and tablet forms offer convenience but may deliver lower concentrations of active compounds.

Where it comes from:

Created by Li Dongyuan (Li Gao) around 1249 CE and documented in his text 'Pi Wei Lun' (Treatise on the Spleen and Stomach), this formula became one of the most celebrated tonics in all of East Asian medicine. It spread to Korea as Bojungikgi-tang and to Japan as Hochu-ekki-to, where it has been the subject of dozens of modern clinical trials, particularly for cancer-related fatigue, immune modulation, and recurrent infections.

What does Bojungikgi-tang (Supplement Middle) help with?

• Chronic fatigue and low energy: This is the formula's primary and most evidence-backed application. It works by supporting the body's energy production at the cellular level and helping regulate stress hormones that drain vitality over time. People with deep, persistent tiredness — especially from overwork, illness, or poor digestion — tend to respond well.
• Cancer-related fatigue (during or after treatment): Several clinical trials, particularly from Japan using the Kampo version (Hochu-ekki-to), have found it helps reduce fatigue in cancer patients undergoing chemotherapy or radiation. It also appears to help support immune cell counts during treatment, making it one of the more researched herbal formulas in integrative oncology.
• Immune system weakness and recurrent infections: The Astragalus and Ginseng in this formula are well-established immune modulators. The formula has been shown to improve natural killer cell activity and increase resistance to respiratory and other infections, making it particularly useful for people who seem to catch every cold going around.
• Digestive weakness and poor appetite: The formula targets the digestive system directly, helping stimulate appetite, improve nutrient absorption, and ease bloating or sluggish digestion. It is especially suited to people whose fatigue is tied to poor eating, malabsorption, or a sensitive gut.
• Organ prolapse (rectal, uterine, gastric): One of the formula's traditional hallmarks, the 'lifting' herbs Bupleurum and Cimicifuga are used to address downward-bearing conditions like uterine, rectal, or stomach prolapse. Some clinical work from Japan and China has supported its use here, though evidence is less robust than for fatigue.
• Post-illness recovery and convalescence: After a serious illness, surgery, or prolonged stress, this formula helps rebuild strength by supporting digestion, blood production, and immune resilience simultaneously. It is a go-to formula in East Asian clinical practice for the recovery phase.
• Allergic rhinitis and seasonal allergies: Japanese Kampo trials have examined Hochu-ekki-to for allergic rhinitis with promising results, suggesting it may reduce nasal symptoms and immune hypersensitivity over a treatment course, likely via immune-regulating activity of Astragalus and Ginseng.
• Anemia and blood deficiency: Dong Quai (Dang Gui) and Jujube support red blood cell production and iron absorption. The formula is commonly used in East Asian medicine when fatigue is accompanied by pallor, dizziness, or signs of mild anemia.

What can Bojungikgi-tang (Supplement Middle) help prevent?

• Recurrent upper respiratory infections in immunocompromised individuals
• Fatigue relapse following cancer treatment

Which foods are rich in Bojungikgi-tang (Supplement Middle)?

Bojungikgi-tang is a multi-herb formula not naturally present in foods. However, you can support the same energy and immune pathways through diet. Prioritize: (1) Bone broth and slow-cooked soups — support gut integrity and nutrient absorption the way the formula does; (2) Astragalus root — can be added to soups or teas as a standalone tonic; (3) Jujube dates — one of the formula's own ingredients, widely available as a food; (4) Ginger and ginger teas — support digestion and circulation; (5) Iron-rich foods (lentils, dark leafy greens, grass-fed beef) — support the blood-nourishing aspect of the formula. Avoid excessive raw, cold, or heavily processed foods, which weaken digestive energy according to the same traditional framework this formula operates within.

What are the side effects of Bojungikgi-tang (Supplement Middle)?

• Mild bloating or gas (especially early in treatment)
• Nausea or digestive discomfort at high doses
• Headache (usually transient during initial use)
• Elevated blood pressure with prolonged high-dose use (due to licorice content)
• Fluid retention in sensitive individuals (licorice-related)
• Allergic reactions in people with known sensitivity to any component herbs
• Insomnia or mild agitation if taken late in the day (stimulating effect of Ginseng)
• Not recommended during pregnancy without practitioner guidance

Good to know:

Bojungikgi-tang has a strong safety record spanning centuries of use and is generally well tolerated at standard doses. Most side effects are mild and transient, especially in the first week of use.

How much Bojungikgi-tang (Supplement Middle) should you take?

• Recommended daily: Granules/powder: 7.5–9 g per day in divided doses (standard Kampo/Hanbang clinical dosing). Decoction: one full decoction per day split into 2–3 doses. Capsules/tablets: follow manufacturer dosing, typically 3–6 capsules per day of standardized extract.
• Best time of day: Morning and early afternoon are preferred. Avoid taking ginseng-containing formulas late in the evening as they may interfere with sleep.
• With or without food: Traditionally taken 30 minutes before meals on an empty stomach for best absorption, or as directed by a practitioner. With food is acceptable if stomach upset occurs.
• Time to effect: Mild energy and digestive improvement: 2–4 weeks. Immune strengthening and structural benefits: 4–12 weeks of consistent use.
• How long to take it: Typically used in 4–8 week courses with a 1–2 week break before resuming, or continuously at lower maintenance doses under practitioner guidance. Not intended as a daily lifelong supplement without periodic reassessment.