Educational information, not medical advice.See how evidence is graded

Dark shadow above my upper lip

You look in the mirror and see a faint brown band above your top lip. It can look like a smudge, or like a shadow that never lifts. Washing does not shift it, and makeup covers it for only a few hours.

The skin above the lip is one of the most common spots for melasma. Melasma means patches of extra brown color in the skin. The mark is often soft at the edges and shows up on both sides.

This mark is flat, not raised, and it does not itch or bleed. It tends to get darker in summer and fade a little in winter. It is a color change, not an illness in the rest of your body.

When to see someone

Book with a skin doctor within a week if the mark is on one side only. Do the same if it is raised, bleeds, crusts, or has a ragged edge.

Also go if it has more than one color, or if it has grown fast. These signs need a look in person.

See your usual doctor soon if your gums, palm lines, knuckles or old scars are going dark too. Go the same day if you also feel very tired, feel faint when you stand, or have lost weight. That mix can point to a gland problem that needs a blood test.

Make an appointment if your periods have stopped or gone odd. Do the same if you grow coarse dark hair on the chin, jaw or chest. A doctor can check your hormones.

Call the doctor who gave you a new medicine if the mark came on soon after you started it. Do not stop the drug on your own first.

Stop any product and get care the same day if the skin blisters, swells, or weeps. Rinse with plain water and go to urgent care if your lip or eye swells.

If you are pregnant or breastfeeding, ask your midwife or doctor before you use any cream or pill on this list.

Why it happens

Your skin has cells that make brown color. Their job is to soak up light and shield the skin below. In melasma, these cells switch on too much in one small patch.

Sun is the main trigger. The strip above the lip sticks out toward the sun and gets light most of the day. Even short daily trips add up over months.

Heat plays a part too, not just light. Hot stoves, hot cars and hot weather can make the patch darker. Some people flare after a sauna or a long walk in the heat.

Hormones are the second big driver. Pregnancy, the pill, the patch, the ring and hormone therapy can all set it off. That is why it shows up so often in women aged 20 to 50.

Rubbing matters as well. Waxing, threading, hard scrubbing and stinging products can stir up the skin. Once that strip is upset, it often heals a shade darker.

What else it could be

Not every dark line above the lip is melasma. The cause changes what helps, so it is worth sorting out first.

Fine dark hair is the top mix-up. A thick layer of soft hair casts a real shadow on the skin.

Run a finger over it, or look in bright side light. If you feel or see hair, the skin under it may be your normal color.

Next is darkening after the skin was upset. This follows waxing, threading, laser, acne, a cold sore, or a rash.

It often traces the exact spot that was sore. It fades on its own over months if you leave that area alone.

A reaction to a product can look the same. Fragrance, lip balm, toothpaste, mouthwash and hair dye can all do it.

The clue is that it itched, burned or looked pink first. A grey brown stain can stay long after the itch is gone.

Some medicines darken the skin. Certain acne antibiotics, seizure drugs and malaria drugs are known for this.

Hormone pills can bring on true melasma. Check if the mark started within a few months of a new drug.

A rare but serious cause is a low output from the adrenal glands. Then the darkening is not just the lip.

Gums, palm lines, scars, knuckles and old scars go darker too. It comes with deep tiredness, weight loss, dizziness on standing, and a craving for salt.

Hormone trouble such as polycystic ovary syndrome can bring coarse dark hair and dark patches together. Missed periods, acne and dark velvet skin on the neck point that way.

One last group is single spots, not a band. A mole, a sun spot or a new growth sits on one side only. If it is raised, changing, or has ragged edges, treat it as a spot to get checked, not as melasma.

How to read the grades below

The options below come from our page on Melasma. Each one carries two labels.

The first label is the evidence grade. A means strong trials in people, B means smaller or mixed studies, and C means early or limited findings. D means lab work only, and “insufficient” means the research cannot settle it yet.

The second label is the traditional tier. T3 means long use in more than one tradition, T2 means long use in one, and T1 means known use. T0 means no such record.

These grades come from research on Melasma, the parent Health Topic, not on dark shadow above my upper lip.

A grade tells you how strong the research is, not how well something will work for you. Talk to a doctor or pharmacist before you start anything, above all if you take other medicines.

What to try first

Start with sun cover. Nothing else works well while the sun keeps switching the color back on. A broad spectrum sun cream in the morning, with more put on at midday, is one option some people use.

A tinted sun cream with iron oxide also blocks visible light. Visible light drives melasma too, so this helps more than a clear one. A wide hat or a light face scarf adds cover on hot days.

Stop what rubs that strip. Skip waxing and threading there while the mark is active. Trim or shave fine hair instead, and drop harsh scrubs and stinging toners.

If hormones may be part of it, talk to your doctor about your pill or patch. Do not stop it on your own. There may be another option that suits you better.

For products, two have the top mark. Tranexamic Acid Serum has an evidence grade A, traditional tier T0. Azelaic acid also has an evidence grade A, traditional tier T0.

Melatonin has an evidence grade A, traditional tier T0. It has been looked at both as a cream and as a pill. Ask your doctor before you take it by mouth.

Next come the B grades. Vitamin C Topical has an evidence grade B, traditional tier T0. Licorice root (Glycyrrhiza glabra) has an evidence grade B, traditional tier T3, so it also has long folk use.

Postbiotic (heat-killed bacteria) has an evidence grade B, traditional tier T0. Vitamin C (Effervescent Powder) has an evidence grade B, traditional tier T0, and is taken by mouth.

Two have weaker proof. Alpha-Arbutin has an evidence grade C, traditional tier T0. Cordyceps has an evidence grade C, traditional tier T3, which means long folk use but thin trial proof.

Three do not have enough proof to grade. Niacinamide (Nicotinamide) is evidence grade insufficient, traditional tier T0.

Glutathione is evidence grade insufficient, traditional tier T0. Acupuncture is evidence grade insufficient, traditional tier T3, so it rests on tradition, not trials.

Add one thing at a time. Dab it on your jaw for three days first to check for stinging. Melasma comes back easily, so slow and gentle beats strong and fast.

How long it takes

Melasma moves slowly. Most people need 8 to 12 weeks of daily care before they see a clear change. Nothing works in a week.

Taking a photo now, and then one each month in the same light, is one way to follow any change. Small fading is hard to spot in the mirror day by day. The photo tells you the truth.

If hormones were the trigger, the mark may fade after birth or after a pill change. That can take 6 months or more. Some marks stay and need ongoing care.

Melasma tends to come back each summer. Keeping up sun cover is what holds any gain you make. No product here can promise a set result.

Melasma: natural remedies and the evidence behind them

15 options · 3 graded B · 4 graded C · 8 traditional or ungraded

How would you like to tackle your melasma?

I want the topicals with the strongest study results, applied right to the patches

  1. Tranexamic Acid Serum

    Supported by smaller clinical studies· Centuries of traditional use (Evidence grade B · Traditional use long-standing)Long-standing traditional staple

    Topical serum with clinical-trial support for melasma

    Why it may be relevant
    A leave-on serum you smooth onto the darker areas, fitting a routine built around creams and serums applied right to the patches.
    Why try it
    In a randomized melasma trial, a 5% topical tranexamic acid cream reduced Melasma Area and Severity Index scores over 12 weeks, offering a gentler topical route than the oral form.
    Dose or use
    Follow product labeling; apply a thin layer to the affected areas (commonly twice daily) and pair with daily sunscreen. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2025, PMID 40923777): Randomized Clinical Trial on the Efficacy of Oral Tranexamic Acid Versus Topical Tranexamic Acid in Treatment of Melasma. Topical 5% tranexamic acid cream applied for 12 weeks significantly reduced MASI scores in melasma patients.
    Caution
    Introduce slowly to check for irritation; stop if the skin becomes red or sensitized and check with your practitioner.
  2. Alpha-Arbutin

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Topical skin-brightening ingredient studied for melasma

    Why it may be relevant
    Alpha-arbutin is a topical cosmetic ingredient clinically compared against prescription creams for melasma.
    Why try it
    Supported by an RCT comparing alpha-arbutin and kojic acid cream to a triple-combination prescription cream for melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 39555866): The Efficacy of Topical Cosmetic Containing Alpha-Arbutin 5% and Kojic Acid 2% Compared With Triple Combination Cream for the Treatment of Melasma: A Split-Face, Evaluator-Blinded Randomized Pilot Stu
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  3. Niacinamide (Nicotinamide)

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Topical ingredient studied for melasma

    Why it may be relevant
    Niacinamide is used in topical creams for melasma; the cited evidence tested it in a topical combination applied to the skin.
    Why try it
    Supported by a randomized, double-blind study comparing niacinamide-containing creams to hydroquinone for melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 41315336): Safety and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical trial.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  4. Azelaic acid

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Topical acid used for melasma and dark spots

    Why it may be relevant
    A naturally occurring acid applied as a cream, gel, or foam directly onto the patches — a natural fit for a topical-first routine.
    Why try it
    Its library profile documents established use for melasma and hyperpigmentation; it also helps calm the inflammation that can accompany uneven tone.
    Dose or use
    Follow product labeling; apply a thin layer to affected areas and use daily sunscreen. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Our library documents azelaic acid's use for melasma and hyperpigmentation; no specific trial is cited here, so it is included as an ungraded topical option.
    Caution
    May cause tingling, dryness, or mild stinging at first; reduce frequency if irritation persists.

I'd rather work on the pigment from the inside with supplements I take by mouth

  1. Glutathione

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Oral antioxidant studied for lightening pigmentation

    Why it may be relevant
    Glutathione taken internally is ideal for those looking to address pigmentation from within through a supplement.
    Why try it
    Explored in a systematic review as a skin-lightening agent, with limited and preliminary evidence in melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–12 weeks
    Key study
    Systematic review (2025, PMID 39444151): Glutathione as a skin-lightening agent and in melasma: a systematic review.
    Caution
    Consult a practitioner if pregnant, breastfeeding, or on medications.
  2. Melatonin

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Oral supplement trialed for facial melasma

    Why it may be relevant
    Oral melatonin is taken internally and has been studied as a supplement for melasma in women.
    Why try it
    Supported by a double-blind, randomized, placebo-controlled trial of oral melatonin for facial melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2024, PMID 38226560): Efficacy of oral 5 mg melatonin in the treatment of facial melasma in women: A double-blind, randomized, placebo-controlled clinical trial.
    Caution
    May cause drowsiness; consult a practitioner if pregnant, breastfeeding, or on hormonal medications.
  3. Vitamin C

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Antioxidant supporting both skin and overall health

    Why it may be relevant
    Vitamin C plays a role both topically and systemically, fitting well for someone taking a combined approach to melasma.
    Why try it
    Oral vitamin C supports the skin's antioxidant defenses as part of an inside-and-out routine; direct evidence for oral effervescent vitamin C changing melasma is lacking.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    General antioxidant support taken by mouth; this specific oral use for melasma has not been confirmed in controlled clinical trials.
    Caution
    High oral doses may cause digestive upset; caution with kidney conditions.

I'm drawn to hands-on, practitioner-led or holistic care (in-clinic or acupressure)

  1. Acupuncture

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Practitioner-delivered treatment for pigmentation

    Why it may be relevant
    Acupuncture is a professional, in-clinic option well suited for those seeking holistic or practitioner-led care.
    Why try it
    Explored in a Bayesian network meta-analysis of TCM therapies for melasma; the pooled trials are small and of limited quality, so the evidence base is early and low-certainty.
    Dose or use
    Work with a qualified, licensed practitioner; ask them how many sessions and how often are right for you.
    Time to results
    Typically 8–16 weeks
    Key study
    Network meta-analysis (2026, PMID 41995533): Comparative effectiveness of acupuncture, fire needle, and herbal therapies for melasma. Pooled several small TCM modalities; findings are low-certainty and not a substitute for standard care.
    Caution
    Seek a licensed acupuncturist; not suitable during pregnancy without clearance.
  2. Postbiotic (heat-killed bacteria)

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · No traditional record)

    Studied only as an add-on to in-clinic procedures

    Why it may be relevant
    The supporting research used this postbiotic strictly as an adjunct to professional IPL and microneedling, so it fits a practitioner-led plan — not a standalone remedy.
    Why try it
    Studied only as an add-on to professional IPL and microneedling, not on its own; any benefit cannot be attributed to the postbiotic by itself.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 41347603): postbiotic formulation combined WITH intense pulsed light and microneedling for melasma. The postbiotic was an adjunct only; its standalone effect for melasma is unproven.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  3. SP6 (Sanyinjiao) - Spleen 6

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    TCM point traditionally used for hormonal balance

    Why it may be relevant
    A hands-on acupressure point you or a practitioner can work, fitting the holistic, practitioner-led path alongside acupuncture.
    Why try it
    Melasma is often hormone-driven, and SP6 — where the Spleen, Liver, and Kidney meridians meet — is traditionally used in TCM for menstrual and hormonal regulation.
    Dose or use
    Locate about three finger-widths above the inner ankle bone; apply firm, steady pressure for 1–2 minutes per side.
    Time to results
    Varies; traditionally used as an ongoing supportive practice
    Key study
    Traditionally used in TCM for hormonal and menstrual balance; this specific use for melasma has not been confirmed in controlled clinical trials.
    Caution
    Traditionally avoided during pregnancy; seek a licensed practitioner if pregnant or trying to conceive.

My skin is reactive — I'd rather start with gentler, botanical brighteners

  1. Cordyceps

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · Traditional use recognised)Recognised traditional use

    Herbal extract studied within a topical cream for melasma

    Why it may be relevant
    Cordyceps has been studied in a topical cosmetic formulation, fitting naturally into a skin-applied routine.
    Why try it
    In a 12-week trial a cordyceps-containing cream, used alongside oral tranexamic acid, performed about as well as a hydroquinone regimen; because both groups also took oral tranexamic acid, the benefit can't be credited to cordyceps on its own.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 40590148): Effect of a New Skin-Lightening Cosmetic Containing Cordyceps Extract in the Treatment of Melasma: A Clinical Trial. Both arms received oral tranexamic acid; the cordyceps cream was comparable to a hydroquinone regimen, so cordyceps' independent effect is not established.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  2. Niacinamide (Nicotinamide)

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Topical ingredient studied for melasma

    Why it may be relevant
    Niacinamide is used in topical creams for melasma; the cited evidence tested it in a topical combination applied to the skin.
    Why try it
    Supported by a randomized, double-blind study comparing niacinamide-containing creams to hydroquinone for melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 41315336): Safety and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical trial.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  3. Vitamin C Topical

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Antioxidant serum applied to brighten dark spots

    Why it may be relevant
    An ascorbic-acid serum applied straight to the skin, a natural fit for a routine focused on topicals you apply to the patches.
    Why try it
    Applied to the skin, vitamin C is an antioxidant used to lighten dark spots and even out tone; our library documents its use for hyperpigmentation.
    Dose or use
    Follow product labeling; apply in the morning and layer daily sunscreen over it. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Our library documents topical vitamin C for hyperpigmentation; no specific melasma trial is cited here, so it is offered as an ungraded topical option.
    Caution
    Can cause mild tingling; introduce gradually and store away from light and air to keep it stable.
  4. Licorice root (Glycyrrhiza glabra)

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Traditionally applied to brighten uneven skin tone

    Why it may be relevant
    Licorice root extract is traditionally used in topical preparations to help reduce the appearance of pigmentation.
    Why try it
    Traditionally used to inhibit melanin production in the skin and even out skin tone.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid prolonged high oral intake; topical use is generally well tolerated.

I want to test for and correct internal shortfalls that could be feeding the patches

  1. Vitamin C

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Antioxidant supporting both skin and overall health

    Why it may be relevant
    Vitamin C plays a role both topically and systemically, fitting well for someone taking a combined approach to melasma.
    Why try it
    Oral vitamin C supports the skin's antioxidant defenses as part of an inside-and-out routine; direct evidence for oral effervescent vitamin C changing melasma is lacking.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    General antioxidant support taken by mouth; this specific oral use for melasma has not been confirmed in controlled clinical trials.
    Caution
    High oral doses may cause digestive upset; caution with kidney conditions.
  2. Vitamin D Deficiency

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Low levels are often reported in melasma

    Why it may be relevant
    Checking and correcting a possible shortfall is an internal, root-cause step for a supplement-based approach taken by mouth.
    Why try it
    Several studies report lower vitamin D in people with melasma; if a blood test shows you are low, correcting it supports overall skin and immune health.
    Dose or use
    Ask your provider to test your levels and dose accordingly; follow product labeling. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks to restore levels
    Key study
    Correcting a documented shortfall can support skin health; this is a root-cause check, not a melasma treatment claim — ask your provider to test your levels.
    Caution
    Vitamin D is fat-soluble and can build up; do not take high doses without testing and practitioner guidance.
  3. Vitamin C Deficiency

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Low levels may affect skin pigmentation repair

    Why it may be relevant
    Checking and correcting a potential deficiency is an internal, root-cause step for those taking a supplement-based approach.
    Why try it
    If you're low in vitamin C, correcting it can support skin antioxidant defenses and overall complexion health.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    Correcting a documented shortfall can support recovery; this is a root-cause check, not a treatment claim — ask your provider to test your levels.
    Caution
    High-dose supplementation may cause digestive upset; check with your practitioner.

Which of these sounds most like your melasma story?

I've tried creams before and it keeps coming back — I want to step things up

  1. Glutathione

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Oral antioxidant studied for lightening pigmentation

    Why it may be relevant
    Glutathione taken internally is ideal for those looking to address pigmentation from within through a supplement.
    Why try it
    Explored in a systematic review as a skin-lightening agent, with limited and preliminary evidence in melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–12 weeks
    Key study
    Systematic review (2025, PMID 39444151): Glutathione as a skin-lightening agent and in melasma: a systematic review.
    Caution
    Consult a practitioner if pregnant, breastfeeding, or on medications.
  2. Melatonin

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Oral supplement trialed for facial melasma

    Why it may be relevant
    Oral melatonin is taken internally and has been studied as a supplement for melasma in women.
    Why try it
    Supported by a double-blind, randomized, placebo-controlled trial of oral melatonin for facial melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2024, PMID 38226560): Efficacy of oral 5 mg melatonin in the treatment of facial melasma in women: A double-blind, randomized, placebo-controlled clinical trial.
    Caution
    May cause drowsiness; consult a practitioner if pregnant, breastfeeding, or on hormonal medications.
  3. Tranexamic Acid Serum

    Supported by smaller clinical studies· Centuries of traditional use (Evidence grade B · Traditional use long-standing)Long-standing traditional staple

    Topical serum with clinical-trial support for melasma

    Why it may be relevant
    A leave-on serum you smooth onto the darker areas, fitting a routine built around creams and serums applied right to the patches.
    Why try it
    In a randomized melasma trial, a 5% topical tranexamic acid cream reduced Melasma Area and Severity Index scores over 12 weeks, offering a gentler topical route than the oral form.
    Dose or use
    Follow product labeling; apply a thin layer to the affected areas (commonly twice daily) and pair with daily sunscreen. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2025, PMID 40923777): Randomized Clinical Trial on the Efficacy of Oral Tranexamic Acid Versus Topical Tranexamic Acid in Treatment of Melasma. Topical 5% tranexamic acid cream applied for 12 weeks significantly reduced MASI scores in melasma patients.
    Caution
    Introduce slowly to check for irritation; stop if the skin becomes red or sensitized and check with your practitioner.
  4. Acupuncture

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Practitioner-delivered treatment for pigmentation

    Why it may be relevant
    Acupuncture is a professional, in-clinic option well suited for those seeking holistic or practitioner-led care.
    Why try it
    Explored in a Bayesian network meta-analysis of TCM therapies for melasma; the pooled trials are small and of limited quality, so the evidence base is early and low-certainty.
    Dose or use
    Work with a qualified, licensed practitioner; ask them how many sessions and how often are right for you.
    Time to results
    Typically 8–16 weeks
    Key study
    Network meta-analysis (2026, PMID 41995533): Comparative effectiveness of acupuncture, fire needle, and herbal therapies for melasma. Pooled several small TCM modalities; findings are low-certainty and not a substitute for standard care.
    Caution
    Seek a licensed acupuncturist; not suitable during pregnancy without clearance.
  5. Cordyceps

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · Traditional use recognised)Recognised traditional use

    Herbal extract studied within a topical cream for melasma

    Why it may be relevant
    Cordyceps has been studied in a topical cosmetic formulation, fitting naturally into a skin-applied routine.
    Why try it
    In a 12-week trial a cordyceps-containing cream, used alongside oral tranexamic acid, performed about as well as a hydroquinone regimen; because both groups also took oral tranexamic acid, the benefit can't be credited to cordyceps on its own.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 40590148): Effect of a New Skin-Lightening Cosmetic Containing Cordyceps Extract in the Treatment of Melasma: A Clinical Trial. Both arms received oral tranexamic acid; the cordyceps cream was comparable to a hydroquinone regimen, so cordyceps' independent effect is not established.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  6. Postbiotic (heat-killed bacteria)

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · No traditional record)

    Studied only as an add-on to in-clinic procedures

    Why it may be relevant
    The supporting research used this postbiotic strictly as an adjunct to professional IPL and microneedling, so it fits a practitioner-led plan — not a standalone remedy.
    Why try it
    Studied only as an add-on to professional IPL and microneedling, not on its own; any benefit cannot be attributed to the postbiotic by itself.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 41347603): postbiotic formulation combined WITH intense pulsed light and microneedling for melasma. The postbiotic was an adjunct only; its standalone effect for melasma is unproven.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.

Mine appeared or flared with pregnancy, birth control, or other hormonal shifts

  1. Melatonin

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Oral supplement trialed for facial melasma

    Why it may be relevant
    Oral melatonin is taken internally and has been studied as a supplement for melasma in women.
    Why try it
    Supported by a double-blind, randomized, placebo-controlled trial of oral melatonin for facial melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2024, PMID 38226560): Efficacy of oral 5 mg melatonin in the treatment of facial melasma in women: A double-blind, randomized, placebo-controlled clinical trial.
    Caution
    May cause drowsiness; consult a practitioner if pregnant, breastfeeding, or on hormonal medications.
  2. Acupuncture

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Practitioner-delivered treatment for pigmentation

    Why it may be relevant
    Acupuncture is a professional, in-clinic option well suited for those seeking holistic or practitioner-led care.
    Why try it
    Explored in a Bayesian network meta-analysis of TCM therapies for melasma; the pooled trials are small and of limited quality, so the evidence base is early and low-certainty.
    Dose or use
    Work with a qualified, licensed practitioner; ask them how many sessions and how often are right for you.
    Time to results
    Typically 8–16 weeks
    Key study
    Network meta-analysis (2026, PMID 41995533): Comparative effectiveness of acupuncture, fire needle, and herbal therapies for melasma. Pooled several small TCM modalities; findings are low-certainty and not a substitute for standard care.
    Caution
    Seek a licensed acupuncturist; not suitable during pregnancy without clearance.
  3. SP6 (Sanyinjiao) - Spleen 6

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    TCM point traditionally used for hormonal balance

    Why it may be relevant
    A hands-on acupressure point you or a practitioner can work, fitting the holistic, practitioner-led path alongside acupuncture.
    Why try it
    Melasma is often hormone-driven, and SP6 — where the Spleen, Liver, and Kidney meridians meet — is traditionally used in TCM for menstrual and hormonal regulation.
    Dose or use
    Locate about three finger-widths above the inner ankle bone; apply firm, steady pressure for 1–2 minutes per side.
    Time to results
    Varies; traditionally used as an ongoing supportive practice
    Key study
    Traditionally used in TCM for hormonal and menstrual balance; this specific use for melasma has not been confirmed in controlled clinical trials.
    Caution
    Traditionally avoided during pregnancy; seek a licensed practitioner if pregnant or trying to conceive.
  4. Vitamin D Deficiency

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Low levels are often reported in melasma

    Why it may be relevant
    Checking and correcting a possible shortfall is an internal, root-cause step for a supplement-based approach taken by mouth.
    Why try it
    Several studies report lower vitamin D in people with melasma; if a blood test shows you are low, correcting it supports overall skin and immune health.
    Dose or use
    Ask your provider to test your levels and dose accordingly; follow product labeling. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks to restore levels
    Key study
    Correcting a documented shortfall can support skin health; this is a root-cause check, not a melasma treatment claim — ask your provider to test your levels.
    Caution
    Vitamin D is fat-soluble and can build up; do not take high doses without testing and practitioner guidance.

It's fairly new or mild — I want a simple, over-the-counter starting routine

  1. Alpha-Arbutin

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Topical skin-brightening ingredient studied for melasma

    Why it may be relevant
    Alpha-arbutin is a topical cosmetic ingredient clinically compared against prescription creams for melasma.
    Why try it
    Supported by an RCT comparing alpha-arbutin and kojic acid cream to a triple-combination prescription cream for melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 39555866): The Efficacy of Topical Cosmetic Containing Alpha-Arbutin 5% and Kojic Acid 2% Compared With Triple Combination Cream for the Treatment of Melasma: A Split-Face, Evaluator-Blinded Randomized Pilot Stu
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  2. Niacinamide (Nicotinamide)

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Topical ingredient studied for melasma

    Why it may be relevant
    Niacinamide is used in topical creams for melasma; the cited evidence tested it in a topical combination applied to the skin.
    Why try it
    Supported by a randomized, double-blind study comparing niacinamide-containing creams to hydroquinone for melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 41315336): Safety and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical trial.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  3. Vitamin C Topical

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Antioxidant serum applied to brighten dark spots

    Why it may be relevant
    An ascorbic-acid serum applied straight to the skin, a natural fit for a routine focused on topicals you apply to the patches.
    Why try it
    Applied to the skin, vitamin C is an antioxidant used to lighten dark spots and even out tone; our library documents its use for hyperpigmentation.
    Dose or use
    Follow product labeling; apply in the morning and layer daily sunscreen over it. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Our library documents topical vitamin C for hyperpigmentation; no specific melasma trial is cited here, so it is offered as an ungraded topical option.
    Caution
    Can cause mild tingling; introduce gradually and store away from light and air to keep it stable.
  4. Licorice root (Glycyrrhiza glabra)

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Traditionally applied to brighten uneven skin tone

    Why it may be relevant
    Licorice root extract is traditionally used in topical preparations to help reduce the appearance of pigmentation.
    Why try it
    Traditionally used to inhibit melanin production in the skin and even out skin tone.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid prolonged high oral intake; topical use is generally well tolerated.
  5. Vitamin C

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Antioxidant supporting both skin and overall health

    Why it may be relevant
    Vitamin C plays a role both topically and systemically, fitting well for someone taking a combined approach to melasma.
    Why try it
    Oral vitamin C supports the skin's antioxidant defenses as part of an inside-and-out routine; direct evidence for oral effervescent vitamin C changing melasma is lacking.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    General antioxidant support taken by mouth; this specific oral use for melasma has not been confirmed in controlled clinical trials.
    Caution
    High oral doses may cause digestive upset; caution with kidney conditions.

Mine darkens with sun and summer — I want antioxidant backup for sun-driven pigment

  1. Azelaic acid

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Topical acid used for melasma and dark spots

    Why it may be relevant
    A naturally occurring acid applied as a cream, gel, or foam directly onto the patches — a natural fit for a topical-first routine.
    Why try it
    Its library profile documents established use for melasma and hyperpigmentation; it also helps calm the inflammation that can accompany uneven tone.
    Dose or use
    Follow product labeling; apply a thin layer to affected areas and use daily sunscreen. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Our library documents azelaic acid's use for melasma and hyperpigmentation; no specific trial is cited here, so it is included as an ungraded topical option.
    Caution
    May cause tingling, dryness, or mild stinging at first; reduce frequency if irritation persists.
  2. Vitamin C Topical

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Antioxidant serum applied to brighten dark spots

    Why it may be relevant
    An ascorbic-acid serum applied straight to the skin, a natural fit for a routine focused on topicals you apply to the patches.
    Why try it
    Applied to the skin, vitamin C is an antioxidant used to lighten dark spots and even out tone; our library documents its use for hyperpigmentation.
    Dose or use
    Follow product labeling; apply in the morning and layer daily sunscreen over it. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Our library documents topical vitamin C for hyperpigmentation; no specific melasma trial is cited here, so it is offered as an ungraded topical option.
    Caution
    Can cause mild tingling; introduce gradually and store away from light and air to keep it stable.
  3. Licorice root (Glycyrrhiza glabra)

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Traditionally applied to brighten uneven skin tone

    Why it may be relevant
    Licorice root extract is traditionally used in topical preparations to help reduce the appearance of pigmentation.
    Why try it
    Traditionally used to inhibit melanin production in the skin and even out skin tone.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid prolonged high oral intake; topical use is generally well tolerated.
  4. Vitamin C

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Antioxidant supporting both skin and overall health

    Why it may be relevant
    Vitamin C plays a role both topically and systemically, fitting well for someone taking a combined approach to melasma.
    Why try it
    Oral vitamin C supports the skin's antioxidant defenses as part of an inside-and-out routine; direct evidence for oral effervescent vitamin C changing melasma is lacking.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    General antioxidant support taken by mouth; this specific oral use for melasma has not been confirmed in controlled clinical trials.
    Caution
    High oral doses may cause digestive upset; caution with kidney conditions.
  5. Vitamin C Deficiency

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Low levels may affect skin pigmentation repair

    Why it may be relevant
    Checking and correcting a potential deficiency is an internal, root-cause step for those taking a supplement-based approach.
    Why try it
    If you're low in vitamin C, correcting it can support skin antioxidant defenses and overall complexion health.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    Correcting a documented shortfall can support recovery; this is a root-cause check, not a treatment claim — ask your provider to test your levels.
    Caution
    High-dose supplementation may cause digestive upset; check with your practitioner.

Evidence grades describe the strength of published research for Melasma, not a promise of results. Nothing here is medical advice — talk to your clinician before starting anything, especially alongside prescription medication.

Questions people ask

Is a dark shadow above the lip the same as a moustache?

No, but the two are easy to mix up. A moustache is hair that you can feel and see in bright side light.

Melasma is a flat color change in the skin itself, with nothing to feel. Some people have both at once, which makes the area look much darker.

Will bleaching cream fix it?

Skin lightening creams can help some people, but strong ones can also backfire. Products with high dose steroids or mercury can thin the skin or leave it darker than before.

Many are sold without clear labels online. Ask a doctor or pharmacist before you use anything that promises fast lightening.

Does waxing my upper lip make the dark mark worse?

It can. Waxing and threading pull and upset that strip of skin, and upset skin often heals a shade darker.

If you already have melasma there, pause hair removal by pulling. Trimming or careful shaving is gentler on the skin.

Can men get melasma above the lip?

Yes. About one in ten people with melasma is a man. In men the trigger is usually sun and heat rather than hormones.

Shaving that same strip every day can also add to the color.

Will it go away after I give birth?

Often it fades in the months after birth as hormone levels settle. For some people it fades only part way, or comes back with the next pregnancy.

Daily sun cover during and after pregnancy gives you the best chance. Ask your midwife or doctor before using any product while pregnant or breastfeeding.

Do I need sunscreen if I stay indoors?

Often yes. Window glass blocks some rays but not all, and visible light from the sun still reaches you near a window.

Melasma also reacts to heat and to bright light, not just to burning rays. A tinted sun cream that contains iron oxide blocks more visible light than a clear one.

Could this be skin cancer?

Melasma itself is not cancer. Warning signs are a single spot on one side, a raised bump, ragged edges, several colors, bleeding, or fast growth. If you see any of those, book with a skin doctor within a week rather than trying creams.

Why does it come back every summer?

The pigment cells in that patch stay easy to switch on, even after the color fades. Longer days and more heat turn them back up. This is why daily sun cover matters all year, not just while the mark is dark.

Other ways people describe this

Same underlying problem, different words.

These suggestions come from our full page on Melasma, where you can see every option and how it is graded. Evidence grades are explained in our methodology, and every phrasing we cover is listed under health topics.

Remedies people try for this

Remedies recommended for the same conditions. Evidence grades are shown on each page.

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Reviewed by the HealisticMD editorial team How we grade evidence →