Educational information, not medical advice.See how evidence is graded

Brown patches on both cheeks

You see flat brown or grey-brown patches on both cheeks. They often match on each side, like a soft mask. The edges look blurry, not sharp.

The skin stays smooth. It does not flake, itch, or hurt. That flat, smooth, even look is a key clue.

This pattern is most often melasma. The colour sits in the upper layers of skin. It can fade a little in winter and come back each summer.

When to see someone

Some brown marks are not melasma. Watch for these signs.

See a skin doctor soon if one patch grows on its own. Do the same if it has ragged edges or mixed colours. Black, red, or white inside a brown patch needs a look.

Go if a spot bleeds, crusts, or scabs over. Go if a sore has not healed in four weeks. Go if the mark is raised or firm.

Call your doctor if dark skin turns up in new places. Check your gums, lips, palm lines, and old scars.

If you also feel weak, dizzy, or you are losing weight, ask for a blood test that week. Go to urgent care or the emergency room if you feel faint, throw up a lot, or have bad belly pain.

Ring the doctor who gave you a new drug if the patches began with it. Do not stop the drug on your own.

Stop any lightening cream that leaves blue-black specks. Take the jar to a skin doctor.

See a doctor if the skin was red, sore, or itchy before it went brown. That points to a reaction, not melasma.

Why it happens

Your skin has colour cells called melanocytes. In melasma, these cells work too hard and make too much brown. Sunlight is the main thing that switches them on.

Hormones play a big part too. Many women first notice it while pregnant or on the pill. That is why people once called it the mask of pregnancy.

Heat and visible light matter as well, not just burning rays. Hot kitchens, saunas, and long drives by a sunny window can all feed it. Plain white sunscreen does not block visible light, so patches can stay dark.

A few drugs raise the risk. So do strong scented products that sting or redden the skin.

What else it could be

Not every brown patch on the cheeks is melasma. The cause changes what you should do, so match your pattern first.

Melasma is flat, smooth, and fairly even on both cheeks, with fuzzy edges. It often reaches the upper lip, forehead, or jaw. It never crusts or itches.

Marks left by old spots or rashes look different. They sit exactly where the acne, eczema, or waxing burn was. They are often patchy, uneven between sides, and fade slowly on their own.

Sun spots and freckles are separate small dots, not one sheet of colour. They have clearer edges and often sit on the nose and hands too. Freckles start in childhood and darken each summer.

A reaction to makeup or scent can leave grey-brown colour on the cheeks. The clue is that the skin was red, itchy, or sore first. Stopping the product is the fix there, not a lightening cream.

Some drugs can stain the skin grey or blue-grey. Long use of strong lightening creams can do the same, with tiny blue-black specks.

Grey-blue speckles on the cheekbones may be a deeper birth-type mark. These sit lower in the skin and do not respond to normal creams.

Rarely, the whole face darkens because of a hormone gland problem. Then gums, lips, palm lines, and old scars go dark too, and you feel tired and weak.

How to read the grades below

The options below come from our page on Melasma. Each one carries two labels.

The first label is the evidence grade. A means strong trials in people, B means smaller or mixed studies, and C means early or limited findings. D means lab work only, and “insufficient” means the research cannot settle it yet.

The second label is the traditional tier. T3 means long use in more than one tradition, T2 means long use in one, and T1 means known use. T0 means no such record.

These grades come from research on Melasma, the parent Health Topic, not on brown patches on both cheeks.

A grade tells you how strong the research is, not how well something will work for you. Talk to a doctor or pharmacist before you start anything, above all if you take other medicines.

What to try first

Start with sun care. It matters more than any cream you buy. Daily sun cream on the face, even when it is grey out, is one option some people rely on.

Pick a tinted one with iron oxide. Tinted cream blocks visible light, which plain sun cream misses. Put it on again at midday if you are outdoors.

Add a wide hat. Sit away from car and office windows. Keep away from steam, ovens, and strong heat.

Then pick one product for the patches. Three choices have the top rating. Azelaic acid has an evidence grade of A.

Tranexamic Acid Serum has an evidence grade of A. Melatonin has an evidence grade of A, and it is taken by mouth, so ask your doctor first.

Four choices have a grade of B. Licorice root (Glycyrrhiza glabra) has an evidence grade of B and a traditional tier of T3. Vitamin C Topical has an evidence grade of B.

Postbiotic (heat-killed bacteria) has an evidence grade of B. Vitamin C (Effervescent Powder) has an evidence grade of B and is taken by mouth.

Two have weaker proof. Alpha-Arbutin has an evidence grade of C. Cordyceps has an evidence grade of C and a traditional tier of T3.

For three, the proof is too thin to judge. Niacinamide (Nicotinamide) has an evidence grade of insufficient. Glutathione has an evidence grade of insufficient.

Acupuncture has an evidence grade of insufficient and a traditional tier of T3, which means long folk use, not trial proof.

Trying one new thing at a time is one way to see what makes a difference. Give it eight weeks before you judge it. Stop if your skin turns red, stings, or peels.

How long it takes

Melasma is slow. Most creams need 8 to 12 weeks before you see a change. Some people need longer.

Taking a photo of your face once a month is one way to track change. Using the same spot and the same light each time makes the photos easier to compare. Day to day, your eyes will miss slow change.

Sun care keeps working the whole time. If you drop it, the colour can come back in weeks. Many people find the patches fade in winter and darken again each summer.

Melasma from pregnancy or the pill often fades over months after the hormone shift ends. It does not always clear fully.

Melasma: natural remedies and the evidence behind them

15 options · 3 graded B · 4 graded C · 8 traditional or ungraded

How would you like to tackle your melasma?

I want the topicals with the strongest study results, applied right to the patches

  1. Tranexamic Acid Serum

    Supported by smaller clinical studies· Centuries of traditional use (Evidence grade B · Traditional use long-standing)Long-standing traditional staple

    Topical serum with clinical-trial support for melasma

    Why it may be relevant
    A leave-on serum you smooth onto the darker areas, fitting a routine built around creams and serums applied right to the patches.
    Why try it
    In a randomized melasma trial, a 5% topical tranexamic acid cream reduced Melasma Area and Severity Index scores over 12 weeks, offering a gentler topical route than the oral form.
    Dose or use
    Follow product labeling; apply a thin layer to the affected areas (commonly twice daily) and pair with daily sunscreen. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2025, PMID 40923777): Randomized Clinical Trial on the Efficacy of Oral Tranexamic Acid Versus Topical Tranexamic Acid in Treatment of Melasma. Topical 5% tranexamic acid cream applied for 12 weeks significantly reduced MASI scores in melasma patients.
    Caution
    Introduce slowly to check for irritation; stop if the skin becomes red or sensitized and check with your practitioner.
  2. Alpha-Arbutin

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Topical skin-brightening ingredient studied for melasma

    Why it may be relevant
    Alpha-arbutin is a topical cosmetic ingredient clinically compared against prescription creams for melasma.
    Why try it
    Supported by an RCT comparing alpha-arbutin and kojic acid cream to a triple-combination prescription cream for melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 39555866): The Efficacy of Topical Cosmetic Containing Alpha-Arbutin 5% and Kojic Acid 2% Compared With Triple Combination Cream for the Treatment of Melasma: A Split-Face, Evaluator-Blinded Randomized Pilot Stu
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  3. Niacinamide (Nicotinamide)

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Topical ingredient studied for melasma

    Why it may be relevant
    Niacinamide is used in topical creams for melasma; the cited evidence tested it in a topical combination applied to the skin.
    Why try it
    Supported by a randomized, double-blind study comparing niacinamide-containing creams to hydroquinone for melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 41315336): Safety and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical trial.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  4. Azelaic acid

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Topical acid used for melasma and dark spots

    Why it may be relevant
    A naturally occurring acid applied as a cream, gel, or foam directly onto the patches — a natural fit for a topical-first routine.
    Why try it
    Its library profile documents established use for melasma and hyperpigmentation; it also helps calm the inflammation that can accompany uneven tone.
    Dose or use
    Follow product labeling; apply a thin layer to affected areas and use daily sunscreen. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Our library documents azelaic acid's use for melasma and hyperpigmentation; no specific trial is cited here, so it is included as an ungraded topical option.
    Caution
    May cause tingling, dryness, or mild stinging at first; reduce frequency if irritation persists.

I'd rather work on the pigment from the inside with supplements I take by mouth

  1. Glutathione

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Oral antioxidant studied for lightening pigmentation

    Why it may be relevant
    Glutathione taken internally is ideal for those looking to address pigmentation from within through a supplement.
    Why try it
    Explored in a systematic review as a skin-lightening agent, with limited and preliminary evidence in melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–12 weeks
    Key study
    Systematic review (2025, PMID 39444151): Glutathione as a skin-lightening agent and in melasma: a systematic review.
    Caution
    Consult a practitioner if pregnant, breastfeeding, or on medications.
  2. Melatonin

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Oral supplement trialed for facial melasma

    Why it may be relevant
    Oral melatonin is taken internally and has been studied as a supplement for melasma in women.
    Why try it
    Supported by a double-blind, randomized, placebo-controlled trial of oral melatonin for facial melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2024, PMID 38226560): Efficacy of oral 5 mg melatonin in the treatment of facial melasma in women: A double-blind, randomized, placebo-controlled clinical trial.
    Caution
    May cause drowsiness; consult a practitioner if pregnant, breastfeeding, or on hormonal medications.
  3. Vitamin C

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Antioxidant supporting both skin and overall health

    Why it may be relevant
    Vitamin C plays a role both topically and systemically, fitting well for someone taking a combined approach to melasma.
    Why try it
    Oral vitamin C supports the skin's antioxidant defenses as part of an inside-and-out routine; direct evidence for oral effervescent vitamin C changing melasma is lacking.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    General antioxidant support taken by mouth; this specific oral use for melasma has not been confirmed in controlled clinical trials.
    Caution
    High oral doses may cause digestive upset; caution with kidney conditions.

I'm drawn to hands-on, practitioner-led or holistic care (in-clinic or acupressure)

  1. Acupuncture

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Practitioner-delivered treatment for pigmentation

    Why it may be relevant
    Acupuncture is a professional, in-clinic option well suited for those seeking holistic or practitioner-led care.
    Why try it
    Explored in a Bayesian network meta-analysis of TCM therapies for melasma; the pooled trials are small and of limited quality, so the evidence base is early and low-certainty.
    Dose or use
    Work with a qualified, licensed practitioner; ask them how many sessions and how often are right for you.
    Time to results
    Typically 8–16 weeks
    Key study
    Network meta-analysis (2026, PMID 41995533): Comparative effectiveness of acupuncture, fire needle, and herbal therapies for melasma. Pooled several small TCM modalities; findings are low-certainty and not a substitute for standard care.
    Caution
    Seek a licensed acupuncturist; not suitable during pregnancy without clearance.
  2. Postbiotic (heat-killed bacteria)

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · No traditional record)

    Studied only as an add-on to in-clinic procedures

    Why it may be relevant
    The supporting research used this postbiotic strictly as an adjunct to professional IPL and microneedling, so it fits a practitioner-led plan — not a standalone remedy.
    Why try it
    Studied only as an add-on to professional IPL and microneedling, not on its own; any benefit cannot be attributed to the postbiotic by itself.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 41347603): postbiotic formulation combined WITH intense pulsed light and microneedling for melasma. The postbiotic was an adjunct only; its standalone effect for melasma is unproven.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  3. SP6 (Sanyinjiao) - Spleen 6

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    TCM point traditionally used for hormonal balance

    Why it may be relevant
    A hands-on acupressure point you or a practitioner can work, fitting the holistic, practitioner-led path alongside acupuncture.
    Why try it
    Melasma is often hormone-driven, and SP6 — where the Spleen, Liver, and Kidney meridians meet — is traditionally used in TCM for menstrual and hormonal regulation.
    Dose or use
    Locate about three finger-widths above the inner ankle bone; apply firm, steady pressure for 1–2 minutes per side.
    Time to results
    Varies; traditionally used as an ongoing supportive practice
    Key study
    Traditionally used in TCM for hormonal and menstrual balance; this specific use for melasma has not been confirmed in controlled clinical trials.
    Caution
    Traditionally avoided during pregnancy; seek a licensed practitioner if pregnant or trying to conceive.

My skin is reactive — I'd rather start with gentler, botanical brighteners

  1. Cordyceps

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · Traditional use recognised)Recognised traditional use

    Herbal extract studied within a topical cream for melasma

    Why it may be relevant
    Cordyceps has been studied in a topical cosmetic formulation, fitting naturally into a skin-applied routine.
    Why try it
    In a 12-week trial a cordyceps-containing cream, used alongside oral tranexamic acid, performed about as well as a hydroquinone regimen; because both groups also took oral tranexamic acid, the benefit can't be credited to cordyceps on its own.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 40590148): Effect of a New Skin-Lightening Cosmetic Containing Cordyceps Extract in the Treatment of Melasma: A Clinical Trial. Both arms received oral tranexamic acid; the cordyceps cream was comparable to a hydroquinone regimen, so cordyceps' independent effect is not established.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  2. Niacinamide (Nicotinamide)

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Topical ingredient studied for melasma

    Why it may be relevant
    Niacinamide is used in topical creams for melasma; the cited evidence tested it in a topical combination applied to the skin.
    Why try it
    Supported by a randomized, double-blind study comparing niacinamide-containing creams to hydroquinone for melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 41315336): Safety and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical trial.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  3. Vitamin C Topical

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Antioxidant serum applied to brighten dark spots

    Why it may be relevant
    An ascorbic-acid serum applied straight to the skin, a natural fit for a routine focused on topicals you apply to the patches.
    Why try it
    Applied to the skin, vitamin C is an antioxidant used to lighten dark spots and even out tone; our library documents its use for hyperpigmentation.
    Dose or use
    Follow product labeling; apply in the morning and layer daily sunscreen over it. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Our library documents topical vitamin C for hyperpigmentation; no specific melasma trial is cited here, so it is offered as an ungraded topical option.
    Caution
    Can cause mild tingling; introduce gradually and store away from light and air to keep it stable.
  4. Licorice root (Glycyrrhiza glabra)

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Traditionally applied to brighten uneven skin tone

    Why it may be relevant
    Licorice root extract is traditionally used in topical preparations to help reduce the appearance of pigmentation.
    Why try it
    Traditionally used to inhibit melanin production in the skin and even out skin tone.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid prolonged high oral intake; topical use is generally well tolerated.

I want to test for and correct internal shortfalls that could be feeding the patches

  1. Vitamin C

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Antioxidant supporting both skin and overall health

    Why it may be relevant
    Vitamin C plays a role both topically and systemically, fitting well for someone taking a combined approach to melasma.
    Why try it
    Oral vitamin C supports the skin's antioxidant defenses as part of an inside-and-out routine; direct evidence for oral effervescent vitamin C changing melasma is lacking.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    General antioxidant support taken by mouth; this specific oral use for melasma has not been confirmed in controlled clinical trials.
    Caution
    High oral doses may cause digestive upset; caution with kidney conditions.
  2. Vitamin D Deficiency

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Low levels are often reported in melasma

    Why it may be relevant
    Checking and correcting a possible shortfall is an internal, root-cause step for a supplement-based approach taken by mouth.
    Why try it
    Several studies report lower vitamin D in people with melasma; if a blood test shows you are low, correcting it supports overall skin and immune health.
    Dose or use
    Ask your provider to test your levels and dose accordingly; follow product labeling. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks to restore levels
    Key study
    Correcting a documented shortfall can support skin health; this is a root-cause check, not a melasma treatment claim — ask your provider to test your levels.
    Caution
    Vitamin D is fat-soluble and can build up; do not take high doses without testing and practitioner guidance.
  3. Vitamin C Deficiency

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Low levels may affect skin pigmentation repair

    Why it may be relevant
    Checking and correcting a potential deficiency is an internal, root-cause step for those taking a supplement-based approach.
    Why try it
    If you're low in vitamin C, correcting it can support skin antioxidant defenses and overall complexion health.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    Correcting a documented shortfall can support recovery; this is a root-cause check, not a treatment claim — ask your provider to test your levels.
    Caution
    High-dose supplementation may cause digestive upset; check with your practitioner.

Which of these sounds most like your melasma story?

I've tried creams before and it keeps coming back — I want to step things up

  1. Glutathione

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Oral antioxidant studied for lightening pigmentation

    Why it may be relevant
    Glutathione taken internally is ideal for those looking to address pigmentation from within through a supplement.
    Why try it
    Explored in a systematic review as a skin-lightening agent, with limited and preliminary evidence in melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–12 weeks
    Key study
    Systematic review (2025, PMID 39444151): Glutathione as a skin-lightening agent and in melasma: a systematic review.
    Caution
    Consult a practitioner if pregnant, breastfeeding, or on medications.
  2. Melatonin

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Oral supplement trialed for facial melasma

    Why it may be relevant
    Oral melatonin is taken internally and has been studied as a supplement for melasma in women.
    Why try it
    Supported by a double-blind, randomized, placebo-controlled trial of oral melatonin for facial melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2024, PMID 38226560): Efficacy of oral 5 mg melatonin in the treatment of facial melasma in women: A double-blind, randomized, placebo-controlled clinical trial.
    Caution
    May cause drowsiness; consult a practitioner if pregnant, breastfeeding, or on hormonal medications.
  3. Tranexamic Acid Serum

    Supported by smaller clinical studies· Centuries of traditional use (Evidence grade B · Traditional use long-standing)Long-standing traditional staple

    Topical serum with clinical-trial support for melasma

    Why it may be relevant
    A leave-on serum you smooth onto the darker areas, fitting a routine built around creams and serums applied right to the patches.
    Why try it
    In a randomized melasma trial, a 5% topical tranexamic acid cream reduced Melasma Area and Severity Index scores over 12 weeks, offering a gentler topical route than the oral form.
    Dose or use
    Follow product labeling; apply a thin layer to the affected areas (commonly twice daily) and pair with daily sunscreen. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2025, PMID 40923777): Randomized Clinical Trial on the Efficacy of Oral Tranexamic Acid Versus Topical Tranexamic Acid in Treatment of Melasma. Topical 5% tranexamic acid cream applied for 12 weeks significantly reduced MASI scores in melasma patients.
    Caution
    Introduce slowly to check for irritation; stop if the skin becomes red or sensitized and check with your practitioner.
  4. Acupuncture

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Practitioner-delivered treatment for pigmentation

    Why it may be relevant
    Acupuncture is a professional, in-clinic option well suited for those seeking holistic or practitioner-led care.
    Why try it
    Explored in a Bayesian network meta-analysis of TCM therapies for melasma; the pooled trials are small and of limited quality, so the evidence base is early and low-certainty.
    Dose or use
    Work with a qualified, licensed practitioner; ask them how many sessions and how often are right for you.
    Time to results
    Typically 8–16 weeks
    Key study
    Network meta-analysis (2026, PMID 41995533): Comparative effectiveness of acupuncture, fire needle, and herbal therapies for melasma. Pooled several small TCM modalities; findings are low-certainty and not a substitute for standard care.
    Caution
    Seek a licensed acupuncturist; not suitable during pregnancy without clearance.
  5. Cordyceps

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · Traditional use recognised)Recognised traditional use

    Herbal extract studied within a topical cream for melasma

    Why it may be relevant
    Cordyceps has been studied in a topical cosmetic formulation, fitting naturally into a skin-applied routine.
    Why try it
    In a 12-week trial a cordyceps-containing cream, used alongside oral tranexamic acid, performed about as well as a hydroquinone regimen; because both groups also took oral tranexamic acid, the benefit can't be credited to cordyceps on its own.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 40590148): Effect of a New Skin-Lightening Cosmetic Containing Cordyceps Extract in the Treatment of Melasma: A Clinical Trial. Both arms received oral tranexamic acid; the cordyceps cream was comparable to a hydroquinone regimen, so cordyceps' independent effect is not established.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  6. Postbiotic (heat-killed bacteria)

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · No traditional record)

    Studied only as an add-on to in-clinic procedures

    Why it may be relevant
    The supporting research used this postbiotic strictly as an adjunct to professional IPL and microneedling, so it fits a practitioner-led plan — not a standalone remedy.
    Why try it
    Studied only as an add-on to professional IPL and microneedling, not on its own; any benefit cannot be attributed to the postbiotic by itself.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 41347603): postbiotic formulation combined WITH intense pulsed light and microneedling for melasma. The postbiotic was an adjunct only; its standalone effect for melasma is unproven.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.

Mine appeared or flared with pregnancy, birth control, or other hormonal shifts

  1. Melatonin

    Supported by smaller clinical studies (Evidence grade B · No traditional record)

    Oral supplement trialed for facial melasma

    Why it may be relevant
    Oral melatonin is taken internally and has been studied as a supplement for melasma in women.
    Why try it
    Supported by a double-blind, randomized, placebo-controlled trial of oral melatonin for facial melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    RCT (2024, PMID 38226560): Efficacy of oral 5 mg melatonin in the treatment of facial melasma in women: A double-blind, randomized, placebo-controlled clinical trial.
    Caution
    May cause drowsiness; consult a practitioner if pregnant, breastfeeding, or on hormonal medications.
  2. Acupuncture

    Centuries of traditional use· Limited human trials so far (Evidence grade C · Traditional use long-standing)Long-standing traditional staple

    Practitioner-delivered treatment for pigmentation

    Why it may be relevant
    Acupuncture is a professional, in-clinic option well suited for those seeking holistic or practitioner-led care.
    Why try it
    Explored in a Bayesian network meta-analysis of TCM therapies for melasma; the pooled trials are small and of limited quality, so the evidence base is early and low-certainty.
    Dose or use
    Work with a qualified, licensed practitioner; ask them how many sessions and how often are right for you.
    Time to results
    Typically 8–16 weeks
    Key study
    Network meta-analysis (2026, PMID 41995533): Comparative effectiveness of acupuncture, fire needle, and herbal therapies for melasma. Pooled several small TCM modalities; findings are low-certainty and not a substitute for standard care.
    Caution
    Seek a licensed acupuncturist; not suitable during pregnancy without clearance.
  3. SP6 (Sanyinjiao) - Spleen 6

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    TCM point traditionally used for hormonal balance

    Why it may be relevant
    A hands-on acupressure point you or a practitioner can work, fitting the holistic, practitioner-led path alongside acupuncture.
    Why try it
    Melasma is often hormone-driven, and SP6 — where the Spleen, Liver, and Kidney meridians meet — is traditionally used in TCM for menstrual and hormonal regulation.
    Dose or use
    Locate about three finger-widths above the inner ankle bone; apply firm, steady pressure for 1–2 minutes per side.
    Time to results
    Varies; traditionally used as an ongoing supportive practice
    Key study
    Traditionally used in TCM for hormonal and menstrual balance; this specific use for melasma has not been confirmed in controlled clinical trials.
    Caution
    Traditionally avoided during pregnancy; seek a licensed practitioner if pregnant or trying to conceive.
  4. Vitamin D Deficiency

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Low levels are often reported in melasma

    Why it may be relevant
    Checking and correcting a possible shortfall is an internal, root-cause step for a supplement-based approach taken by mouth.
    Why try it
    Several studies report lower vitamin D in people with melasma; if a blood test shows you are low, correcting it supports overall skin and immune health.
    Dose or use
    Ask your provider to test your levels and dose accordingly; follow product labeling. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks to restore levels
    Key study
    Correcting a documented shortfall can support skin health; this is a root-cause check, not a melasma treatment claim — ask your provider to test your levels.
    Caution
    Vitamin D is fat-soluble and can build up; do not take high doses without testing and practitioner guidance.

It's fairly new or mild — I want a simple, over-the-counter starting routine

  1. Alpha-Arbutin

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Topical skin-brightening ingredient studied for melasma

    Why it may be relevant
    Alpha-arbutin is a topical cosmetic ingredient clinically compared against prescription creams for melasma.
    Why try it
    Supported by an RCT comparing alpha-arbutin and kojic acid cream to a triple-combination prescription cream for melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 39555866): The Efficacy of Topical Cosmetic Containing Alpha-Arbutin 5% and Kojic Acid 2% Compared With Triple Combination Cream for the Treatment of Melasma: A Split-Face, Evaluator-Blinded Randomized Pilot Stu
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  2. Niacinamide (Nicotinamide)

    Limited human trials so far· Most of the research is laboratory or animal work (Evidence grade C · No traditional record)

    Topical ingredient studied for melasma

    Why it may be relevant
    Niacinamide is used in topical creams for melasma; the cited evidence tested it in a topical combination applied to the skin.
    Why try it
    Supported by a randomized, double-blind study comparing niacinamide-containing creams to hydroquinone for melasma.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    RCT (2025, PMID 41315336): Safety and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical trial.
    Caution
    Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.
  3. Vitamin C Topical

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Antioxidant serum applied to brighten dark spots

    Why it may be relevant
    An ascorbic-acid serum applied straight to the skin, a natural fit for a routine focused on topicals you apply to the patches.
    Why try it
    Applied to the skin, vitamin C is an antioxidant used to lighten dark spots and even out tone; our library documents its use for hyperpigmentation.
    Dose or use
    Follow product labeling; apply in the morning and layer daily sunscreen over it. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Our library documents topical vitamin C for hyperpigmentation; no specific melasma trial is cited here, so it is offered as an ungraded topical option.
    Caution
    Can cause mild tingling; introduce gradually and store away from light and air to keep it stable.
  4. Licorice root (Glycyrrhiza glabra)

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Traditionally applied to brighten uneven skin tone

    Why it may be relevant
    Licorice root extract is traditionally used in topical preparations to help reduce the appearance of pigmentation.
    Why try it
    Traditionally used to inhibit melanin production in the skin and even out skin tone.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid prolonged high oral intake; topical use is generally well tolerated.
  5. Vitamin C

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Antioxidant supporting both skin and overall health

    Why it may be relevant
    Vitamin C plays a role both topically and systemically, fitting well for someone taking a combined approach to melasma.
    Why try it
    Oral vitamin C supports the skin's antioxidant defenses as part of an inside-and-out routine; direct evidence for oral effervescent vitamin C changing melasma is lacking.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    General antioxidant support taken by mouth; this specific oral use for melasma has not been confirmed in controlled clinical trials.
    Caution
    High oral doses may cause digestive upset; caution with kidney conditions.

Mine darkens with sun and summer — I want antioxidant backup for sun-driven pigment

  1. Azelaic acid

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Topical acid used for melasma and dark spots

    Why it may be relevant
    A naturally occurring acid applied as a cream, gel, or foam directly onto the patches — a natural fit for a topical-first routine.
    Why try it
    Its library profile documents established use for melasma and hyperpigmentation; it also helps calm the inflammation that can accompany uneven tone.
    Dose or use
    Follow product labeling; apply a thin layer to affected areas and use daily sunscreen. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Our library documents azelaic acid's use for melasma and hyperpigmentation; no specific trial is cited here, so it is included as an ungraded topical option.
    Caution
    May cause tingling, dryness, or mild stinging at first; reduce frequency if irritation persists.
  2. Vitamin C Topical

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Antioxidant serum applied to brighten dark spots

    Why it may be relevant
    An ascorbic-acid serum applied straight to the skin, a natural fit for a routine focused on topicals you apply to the patches.
    Why try it
    Applied to the skin, vitamin C is an antioxidant used to lighten dark spots and even out tone; our library documents its use for hyperpigmentation.
    Dose or use
    Follow product labeling; apply in the morning and layer daily sunscreen over it. Consult a healthcare practitioner.
    Time to results
    Typically 8–12 weeks
    Key study
    Our library documents topical vitamin C for hyperpigmentation; no specific melasma trial is cited here, so it is offered as an ungraded topical option.
    Caution
    Can cause mild tingling; introduce gradually and store away from light and air to keep it stable.
  3. Licorice root (Glycyrrhiza glabra)

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Traditionally applied to brighten uneven skin tone

    Why it may be relevant
    Licorice root extract is traditionally used in topical preparations to help reduce the appearance of pigmentation.
    Why try it
    Traditionally used to inhibit melanin production in the skin and even out skin tone.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.
    Caution
    Avoid prolonged high oral intake; topical use is generally well tolerated.
  4. Vitamin C

    Not yet assessed· We have not reviewed the literature for this one (Evidence grade not assigned · Traditional use recognised)Recognised traditional use

    Antioxidant supporting both skin and overall health

    Why it may be relevant
    Vitamin C plays a role both topically and systemically, fitting well for someone taking a combined approach to melasma.
    Why try it
    Oral vitamin C supports the skin's antioxidant defenses as part of an inside-and-out routine; direct evidence for oral effervescent vitamin C changing melasma is lacking.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    General antioxidant support taken by mouth; this specific oral use for melasma has not been confirmed in controlled clinical trials.
    Caution
    High oral doses may cause digestive upset; caution with kidney conditions.
  5. Vitamin C Deficiency

    Centuries of traditional use· Human evidence not yet assessed (Evidence grade not assigned · Traditional use long-standing)Long-standing traditional staple

    Low levels may affect skin pigmentation repair

    Why it may be relevant
    Checking and correcting a potential deficiency is an internal, root-cause step for those taking a supplement-based approach.
    Why try it
    If you're low in vitamin C, correcting it can support skin antioxidant defenses and overall complexion health.
    Dose or use
    Follow product labeling; consult a healthcare practitioner.
    Time to results
    Typically 4–8 weeks
    Key study
    Correcting a documented shortfall can support recovery; this is a root-cause check, not a treatment claim — ask your provider to test your levels.
    Caution
    High-dose supplementation may cause digestive upset; check with your practitioner.

Evidence grades describe the strength of published research for Melasma, not a promise of results. Nothing here is medical advice — talk to your clinician before starting anything, especially alongside prescription medication.

Questions people ask

Is melasma the same as sun spots?

No. Sun spots are small, separate dots with clear edges, and they often sit on the nose, hands, and arms too.

Melasma is a larger, blurry patch that usually matches on both cheeks. They need different care, so it helps to know which one you have.

Will melasma go away after I give birth?

It often fades over the months after the birth, as hormone levels settle. Some colour may stay, though. Daily sun care during and after pregnancy gives it the best chance to fade.

Is sunscreen alone enough?

Sun care is the base of any melasma plan, and skipping it undoes other efforts. A tinted sun cream with iron oxide works better than a plain one, because it also blocks visible light. Most people still need a cream for the patches on top of that.

Can melasma turn into skin cancer?

Melasma itself is not cancer and does not become cancer. But one patch that grows on its own, has ragged edges, mixed colours, or bleeds is a different problem and needs a skin doctor. When in doubt about a single odd patch, get it checked.

Why does it come back every summer?

Sunlight switches on the colour cells that cause melasma. In winter you get less light, so the patches can fade. In summer the same cells wake up again, so the colour returns unless you keep up sun care all year.

Can heat make it worse even without sun?

Yes. Heat alone can push the colour cells to work harder. Hot ovens, saunas, steam, and hot yoga rooms can all add to it, so keeping cool is part of the plan.

Do men get brown patches on both cheeks?

Yes, though it is less common than in women. In men it is linked more to sun and heat than to hormones. The look is the same: flat, smooth, blurry patches that match on each side.

Are strong salon treatments a fast fix?

Melasma can flare after treatments that heat or irritate the skin, so a fast fix can backfire. Any in-clinic option should be planned by a skin doctor who knows your skin tone. Ask what the plan is if the patches get darker instead of lighter.

Can I mix home acids to lighten the patches?

Harsh home mixes can burn the skin and leave darker marks than you started with. Any redness or stinging can make melasma flare. Stick with products made for the face and test a small area first.

Other ways people describe this

Same underlying problem, different words.

These suggestions come from our full page on Melasma, where you can see every option and how it is graded. Evidence grades are explained in our methodology, and every phrasing we cover is listed under health topics.

Remedies people try for this

Remedies recommended for the same conditions. Evidence grades are shown on each page.

See your options in the app

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Reviewed by the HealisticMD editorial team How we grade evidence →