Educational information, not medical advice.See how evidence is graded

Heartburn: natural remedies and the evidence behind them

14 natural approaches to Heartburn, graded by evidence — including Alginate-Based Formulations, Acupuncture and DGL Licorice.

14 options1 graded A2 graded B3 graded C8 traditional or ungraded

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When does your heartburn tend to strike?

At night — it flares when I lie down or wakes me up

Natural remedy

Alginate-Based Formulations

Evidence grade A · Traditional use not yet assessed

Forms a gel raft that blocks nighttime reflux

Why it may be relevant

For heartburn when you lie down, an alginate forms a floating gel barrier over the stomach contents that can help physically block acid from rising into the esophagus.

Supported by controlled trials: alginate forms a gel 'raft' over the stomach that reduces reflux symptoms, a mechanism well suited to lying-down reflux.

Dose or use Follow product labeling; alginate formulas are typically taken after meals and at bedtime. Consult a healthcare practitioner.

Key study Systematic review and meta-analysis of RCTs (2017, PMID 28375448): alginate-based therapies increased the odds of resolving GERD symptoms versus placebo or antacids (OR 4.42), though they appear less effective than acid-suppressing drugs such as PPIs.

EvidenceSupported by controlled trialsTime to resultsOften noticeable within the first few days
Caution: Some alginate formulas contain sodium or potassium bicarbonate; consult your doctor if you are on a sodium-restricted diet or have kidney disease.
Read the evidence →

Natural remedy

Melatonin

Evidence grade C · No traditional record

Trial evidence as a nighttime add-on

Why it may be relevant

For heartburn that worsens when you lie down, melatonin may help support the lower esophageal sphincter and protect the esophageal lining overnight; a small trial tested it added to standard acid-reducing treatment.

Best known for supporting sleep, melatonin was tested as an add-on to omeprazole in one randomized trial and modestly improved heartburn; it has not been shown to work on its own and the finding needs confirmation.

Dose or use Commonly taken as about 3 mg at bedtime in studies; follow product labeling and consult a healthcare practitioner.

Key study Randomized, double-blind trial (2023, PMID 37768310): sublingual melatonin 3 mg added to omeprazole significantly reduced heartburn and reflux symptom scores versus omeprazole plus placebo in 72 adults with GERD; melatonin was not tested on its own.

EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 2–4 weeks
Caution: May cause drowsiness; consult a doctor if on blood thinners or immunosuppressants.
Read the evidence →

Natural remedy

Chamomile

Evidence grade not assigned · Traditional use recognised

Traditionally calms both nerves and digestion

Why it may be relevant

When stress sets off your heartburn, chamomile is traditionally used for its calming effect while also soothing an unsettled stomach.

Traditionally used to ease tension and relax the digestive tract, addressing both the stress and the stomach side of stress-driven heartburn.

Dose or use Follow product labeling; commonly taken as a tea after meals or in the evening. Consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 2-4 weeksTraditional useRecognised traditional use
Caution: Avoid if allergic to ragweed, daisies, or related plants; may interact with blood thinners and sedatives.
Read the evidence →

When does your heartburn tend to strike?

Right after meals — certain foods or big dinners set it off

Natural remedy

Alginate-Based Formulations

Evidence grade A · Traditional use not yet assessed

Forms a gel raft that blocks nighttime reflux

Why it may be relevant

For heartburn when you lie down, an alginate forms a floating gel barrier over the stomach contents that can help physically block acid from rising into the esophagus.

Supported by controlled trials: alginate forms a gel 'raft' over the stomach that reduces reflux symptoms, a mechanism well suited to lying-down reflux.

Dose or use Follow product labeling; alginate formulas are typically taken after meals and at bedtime. Consult a healthcare practitioner.

Key study Systematic review and meta-analysis of RCTs (2017, PMID 28375448): alginate-based therapies increased the odds of resolving GERD symptoms versus placebo or antacids (OR 4.42), though they appear less effective than acid-suppressing drugs such as PPIs.

EvidenceSupported by controlled trialsTime to resultsOften noticeable within the first few days
Caution: Some alginate formulas contain sodium or potassium bicarbonate; consult your doctor if you are on a sodium-restricted diet or have kidney disease.
Read the evidence →

Natural remedy

DGL Licorice

Evidence grade B · Traditional use recognised

RCT evidence for easing heartburn

Why it may be relevant

For post-meal burning, deglycyrrhizinated licorice (DGL) may support the protective mucus that coats the stomach and esophageal lining. In a randomized trial, a standardized DGL extract eased heartburn faster than placebo.

A double-blind, placebo-controlled trial found a standardized deglycyrrhizinated licorice extract improved heartburn, regurgitation, and quality of life; the 'DGL' form is chosen to avoid the blood-pressure and potassium effects of whole licorice.

Dose or use Follow product labeling; DGL is often taken as a chewable tablet before or between meals. Consult a healthcare practitioner.

Key study Randomized, double-blind, placebo-controlled Phase III trial (2025, PMID 39929150): a standardized deglycyrrhizinated licorice extract (GutGard) produced earlier resolution of heartburn (p=0.005 at day 28) and regurgitation versus placebo in 200 adults with reflux symptoms.

EvidenceSupported by smaller clinical studies · Recognised traditional useTime to resultsTypically 2-4 weeksTraditional useRecognised traditional use
Caution: Choose the deglycyrrhizinated (DGL) form to avoid the blood-pressure and potassium effects of whole licorice; consult your doctor if pregnant or on medications.
Read the evidence →

Natural remedy

Ginger

Evidence grade C · No traditional record

Trial data in functional dyspepsia

Why it may be relevant

When heartburn follows meals, ginger may support healthy gastric motility; a trial in functional dyspepsia found a steamed ginger extract improved digestive symptoms, including a reflux subscore.

Traditionally used to ease nausea and stomach upset, ginger also improved reflux and indigestion scores in a randomized trial of people with functional dyspepsia - promising, though not a direct heartburn study.

Dose or use Commonly taken as a standardized extract or with food; follow product labeling and consult a healthcare practitioner.

Key study Randomized, double-blind, placebo-controlled trial (2025, PMID 40878144): a steamed ginger extract improved overall GI symptom scores, including the reflux and indigestion subscores, versus placebo in 80 adults with functional dyspepsia (not GERD-specific).

EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 2–4 weeks
Caution: High doses may worsen reflux in some people; consult a doctor if on blood thinners.
Read the evidence →

Pressure point

REN12 (Zhongwan)

Evidence grade not assigned · Traditional use long-standing

Traditionally used for acid reflux and indigestion

Why it may be relevant

When heartburn flares after eating, this traditionally used point on the mid-abdomen is believed to support the stomach and ease indigestion.

Traditionally used in Chinese medicine as a central digestive point to relieve acid reflux, bloating, and stomach discomfort.

Dose or use Press gently for 2-3 minutes on the midline of the abdomen, about halfway between the navel and the base of the breastbone, 1-2x daily.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsMay offer comfort within minutes; ongoing use for broader benefitTraditional useLong-standing traditional staple
Caution: Use gentle pressure only; avoid firm abdominal pressure if pregnant or after recent abdominal surgery.

Natural remedy

Slippery Elm (Ulmus rubra)

Evidence grade not assigned · Traditional use recognised

Traditionally used to coat and soothe the gut

Why it may be relevant

When burning follows meals, slippery elm is traditionally used because its mucilage forms a slick coating that can soothe an irritated esophagus and stomach.

Traditionally used as a demulcent: its mucilage coats the digestive tract and may help shield irritated tissue from acid.

Dose or use Follow product labeling; often taken as a powder mixed with water or as capsules/lozenges after meals. Consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 2-4 weeksTraditional useRecognised traditional use
Caution: Its coating action can slow absorption of other medicines - take it a couple of hours apart from prescriptions; consult your doctor if pregnant.
Read the evidence →

Pressure point

ST36 (Zusanli)

Evidence grade not assigned · Traditional use long-standing

Traditionally supports digestive function

Why it may be relevant

When heartburn flares after eating, this traditionally used point on the lower leg is believed to support overall digestive tone.

Traditionally used to strengthen digestive energy and ease stomach discomfort after meals.

Dose or use Press firmly 2–3 minutes on the outer lower leg (four finger-widths below the kneecap, one finger-width outside the shinbone), both sides, 1–2x daily.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsMay offer comfort within minutes; ongoing use for broader benefitTraditional useLong-standing traditional staple
Caution: Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.

What kind of help sounds most like you?

I want something I can feel working fast — in minutes or days, not weeks

Natural remedy

Alginate-Based Formulations

Evidence grade A · Traditional use not yet assessed

Forms a gel raft that blocks nighttime reflux

Why it may be relevant

For heartburn when you lie down, an alginate forms a floating gel barrier over the stomach contents that can help physically block acid from rising into the esophagus.

Supported by controlled trials: alginate forms a gel 'raft' over the stomach that reduces reflux symptoms, a mechanism well suited to lying-down reflux.

Dose or use Follow product labeling; alginate formulas are typically taken after meals and at bedtime. Consult a healthcare practitioner.

Key study Systematic review and meta-analysis of RCTs (2017, PMID 28375448): alginate-based therapies increased the odds of resolving GERD symptoms versus placebo or antacids (OR 4.42), though they appear less effective than acid-suppressing drugs such as PPIs.

EvidenceSupported by controlled trialsTime to resultsOften noticeable within the first few days
Caution: Some alginate formulas contain sodium or potassium bicarbonate; consult your doctor if you are on a sodium-restricted diet or have kidney disease.
Read the evidence →

Pressure point

PC6 (Neiguan) - Pericardium 6

Evidence grade not assigned · Traditional use long-standing

Traditionally used to calm stomach and nausea

Why it may be relevant

When stress and tension accompany heartburn, this traditionally used pressure point on the inner wrist is believed to ease digestive discomfort.

Traditionally used to settle the stomach, ease nausea, and support relaxation of the upper digestive tract.

Dose or use Press firmly 2–3 minutes on the inner wrist (two finger-widths below the wrist crease, between the tendons), both sides, 1–2x daily.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsMay offer comfort within minutes; ongoing use for broader benefitTraditional useLong-standing traditional staple
Caution: Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.

Pressure point

REN12 (Zhongwan)

Evidence grade not assigned · Traditional use long-standing

Traditionally used for acid reflux and indigestion

Why it may be relevant

When heartburn flares after eating, this traditionally used point on the mid-abdomen is believed to support the stomach and ease indigestion.

Traditionally used in Chinese medicine as a central digestive point to relieve acid reflux, bloating, and stomach discomfort.

Dose or use Press gently for 2-3 minutes on the midline of the abdomen, about halfway between the navel and the base of the breastbone, 1-2x daily.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsMay offer comfort within minutes; ongoing use for broader benefitTraditional useLong-standing traditional staple
Caution: Use gentle pressure only; avoid firm abdominal pressure if pregnant or after recent abdominal surgery.

Pressure point

ST36 (Zusanli)

Evidence grade not assigned · Traditional use long-standing

Traditionally supports digestive function

Why it may be relevant

When heartburn flares after eating, this traditionally used point on the lower leg is believed to support overall digestive tone.

Traditionally used to strengthen digestive energy and ease stomach discomfort after meals.

Dose or use Press firmly 2–3 minutes on the outer lower leg (four finger-widths below the kneecap, one finger-width outside the shinbone), both sides, 1–2x daily.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsMay offer comfort within minutes; ongoing use for broader benefitTraditional useLong-standing traditional staple
Caution: Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.

When does your heartburn tend to strike?

It's constant — I want to work on the root cause, not just flare-ups

Natural remedy

Acupuncture

Evidence grade B · Traditional use long-standing

Meta-analysis suggests reflux symptom relief

Why it may be relevant

When stress is a key trigger, acupuncture may help calm the gut-brain signalling that can drive reflux; pooled trial data also point to reduced reflux symptom scores.

A meta-analysis of randomized trials found manual acupuncture improved GERD symptom scores and reduced recurrence, though the trials were small and varied so the certainty of this evidence is low.

Dose or use See a licensed acupuncturist for a course of sessions (often weekly over several weeks). This is a practitioner-delivered therapy, not a self-administered product.

Key study Systematic review and trial-sequential meta-analysis (2025, PMID 40127634): manual acupuncture improved GERD symptom scores (mean difference -3.43) and lowered recurrence versus controls, but GRADE certainty was very low due to heterogeneity and study quality.

EvidenceSupported by smaller clinical studies · Centuries of traditional useTime to resultsTypically 4-8 weeks of regular sessionsTraditional useLong-standing traditional staple
Caution: Seek a licensed acupuncturist; disclose any bleeding disorders, pregnancy, or medications such as blood thinners.
Read the evidence →

Natural remedy

Probiotics (Lactobacillus plantarum P8)

Evidence grade C · No traditional record

Early trial evidence as an add-on therapy

Why it may be relevant

For ongoing, persistent heartburn, rebalancing the gut microbiome may help address an underlying driver of chronic reflux.

One recent trial suggests this strain, taken alongside standard reflux treatment, may help sustain symptom relief. It has not been shown to work on its own, and the finding awaits confirmation in further studies.

Dose or use Follow product labeling; consult a healthcare practitioner.

Key study Single RCT (2026, PMID 41609355) of adjunctive (add-on) probiotic therapy alongside standard GERD treatment; the strain was not tested by itself, and results have not yet been replicated.

EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 4–8 weeks
Caution: Consult your doctor if immunocompromised before starting probiotics.
Read the evidence →

Natural remedy

Aloe Vera Juice

Evidence grade not assigned · No traditional record

Traditionally used to soothe the digestive tract

Why it may be relevant

For post-meal burning, aloe vera juice is traditionally used to help coat and soothe the esophagus and stomach lining.

Traditionally used for its soothing, anti-inflammatory properties along the digestive tract to ease irritation.

Dose or use Follow product labeling; consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 2–4 weeks
Caution: Use decolorized, purified aloe vera juice; avoid if pregnant or on diabetes or diuretic medications.
Read the evidence →

Natural remedy

Magnesium

Evidence grade not assigned · No traditional record

Low levels may affect muscle and digestive tone

Why it may be relevant

If you're dealing with persistent heartburn, checking whether you're low in magnesium is worthwhile — correcting a deficiency may support healthy muscle tone in the digestive tract.

Magnesium plays a role in smooth muscle relaxation; if you're low, correcting it may help support normal lower esophageal sphincter function.

Dose or use Follow product labeling; consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 4–8 weeks
Caution: Consult a doctor if you have kidney disease; high doses can cause loose stools.
Read the evidence →

Natural remedy

Slippery Elm (Ulmus rubra)

Evidence grade not assigned · Traditional use recognised

Traditionally used to coat and soothe the gut

Why it may be relevant

When burning follows meals, slippery elm is traditionally used because its mucilage forms a slick coating that can soothe an irritated esophagus and stomach.

Traditionally used as a demulcent: its mucilage coats the digestive tract and may help shield irritated tissue from acid.

Dose or use Follow product labeling; often taken as a powder mixed with water or as capsules/lozenges after meals. Consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 2-4 weeksTraditional useRecognised traditional use
Caution: Its coating action can slow absorption of other medicines - take it a couple of hours apart from prescriptions; consult your doctor if pregnant.
Read the evidence →

When does your heartburn tend to strike?

When I'm stressed or tense — my stomach feels the pressure

Natural remedy

Acupuncture

Evidence grade B · Traditional use long-standing

Meta-analysis suggests reflux symptom relief

Why it may be relevant

When stress is a key trigger, acupuncture may help calm the gut-brain signalling that can drive reflux; pooled trial data also point to reduced reflux symptom scores.

A meta-analysis of randomized trials found manual acupuncture improved GERD symptom scores and reduced recurrence, though the trials were small and varied so the certainty of this evidence is low.

Dose or use See a licensed acupuncturist for a course of sessions (often weekly over several weeks). This is a practitioner-delivered therapy, not a self-administered product.

Key study Systematic review and trial-sequential meta-analysis (2025, PMID 40127634): manual acupuncture improved GERD symptom scores (mean difference -3.43) and lowered recurrence versus controls, but GRADE certainty was very low due to heterogeneity and study quality.

EvidenceSupported by smaller clinical studies · Centuries of traditional useTime to resultsTypically 4-8 weeks of regular sessionsTraditional useLong-standing traditional staple
Caution: Seek a licensed acupuncturist; disclose any bleeding disorders, pregnancy, or medications such as blood thinners.
Read the evidence →

Natural remedy

Ashwagandha

Evidence grade not assigned · Traditional use long-standing

Traditionally used to ease stress-driven symptoms

Why it may be relevant

When stress is a clear heartburn trigger, this adaptogenic herb is traditionally used to help the body manage tension that can aggravate digestion.

Traditionally used as an adaptogen to support the nervous system and reduce the physical effects of stress on the body.

Dose or use Follow product labeling; consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsTypically 4–8 weeksTraditional useLong-standing traditional staple
Caution: Avoid in pregnancy; may interact with thyroid medications and sedatives.
Read the evidence →

Natural remedy

Chamomile

Evidence grade not assigned · Traditional use recognised

Traditionally calms both nerves and digestion

Why it may be relevant

When stress sets off your heartburn, chamomile is traditionally used for its calming effect while also soothing an unsettled stomach.

Traditionally used to ease tension and relax the digestive tract, addressing both the stress and the stomach side of stress-driven heartburn.

Dose or use Follow product labeling; commonly taken as a tea after meals or in the evening. Consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 2-4 weeksTraditional useRecognised traditional use
Caution: Avoid if allergic to ragweed, daisies, or related plants; may interact with blood thinners and sedatives.
Read the evidence →

Pressure point

PC6 (Neiguan) - Pericardium 6

Evidence grade not assigned · Traditional use long-standing

Traditionally used to calm stomach and nausea

Why it may be relevant

When stress and tension accompany heartburn, this traditionally used pressure point on the inner wrist is believed to ease digestive discomfort.

Traditionally used to settle the stomach, ease nausea, and support relaxation of the upper digestive tract.

Dose or use Press firmly 2–3 minutes on the inner wrist (two finger-widths below the wrist crease, between the tendons), both sides, 1–2x daily.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsMay offer comfort within minutes; ongoing use for broader benefitTraditional useLong-standing traditional staple
Caution: Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.

What kind of help sounds most like you?

I'd rather calm the stress-and-tension side that stirs up my gut

Natural remedy

Acupuncture

Evidence grade B · Traditional use long-standing

Meta-analysis suggests reflux symptom relief

Why it may be relevant

When stress is a key trigger, acupuncture may help calm the gut-brain signalling that can drive reflux; pooled trial data also point to reduced reflux symptom scores.

A meta-analysis of randomized trials found manual acupuncture improved GERD symptom scores and reduced recurrence, though the trials were small and varied so the certainty of this evidence is low.

Dose or use See a licensed acupuncturist for a course of sessions (often weekly over several weeks). This is a practitioner-delivered therapy, not a self-administered product.

Key study Systematic review and trial-sequential meta-analysis (2025, PMID 40127634): manual acupuncture improved GERD symptom scores (mean difference -3.43) and lowered recurrence versus controls, but GRADE certainty was very low due to heterogeneity and study quality.

EvidenceSupported by smaller clinical studies · Centuries of traditional useTime to resultsTypically 4-8 weeks of regular sessionsTraditional useLong-standing traditional staple
Caution: Seek a licensed acupuncturist; disclose any bleeding disorders, pregnancy, or medications such as blood thinners.
Read the evidence →

Natural remedy

Ashwagandha

Evidence grade not assigned · Traditional use long-standing

Traditionally used to ease stress-driven symptoms

Why it may be relevant

When stress is a clear heartburn trigger, this adaptogenic herb is traditionally used to help the body manage tension that can aggravate digestion.

Traditionally used as an adaptogen to support the nervous system and reduce the physical effects of stress on the body.

Dose or use Follow product labeling; consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsTypically 4–8 weeksTraditional useLong-standing traditional staple
Caution: Avoid in pregnancy; may interact with thyroid medications and sedatives.
Read the evidence →

Natural remedy

Chamomile

Evidence grade not assigned · Traditional use recognised

Traditionally calms both nerves and digestion

Why it may be relevant

When stress sets off your heartburn, chamomile is traditionally used for its calming effect while also soothing an unsettled stomach.

Traditionally used to ease tension and relax the digestive tract, addressing both the stress and the stomach side of stress-driven heartburn.

Dose or use Follow product labeling; commonly taken as a tea after meals or in the evening. Consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 2-4 weeksTraditional useRecognised traditional use
Caution: Avoid if allergic to ragweed, daisies, or related plants; may interact with blood thinners and sedatives.
Read the evidence →

Pressure point

PC6 (Neiguan) - Pericardium 6

Evidence grade not assigned · Traditional use long-standing

Traditionally used to calm stomach and nausea

Why it may be relevant

When stress and tension accompany heartburn, this traditionally used pressure point on the inner wrist is believed to ease digestive discomfort.

Traditionally used to settle the stomach, ease nausea, and support relaxation of the upper digestive tract.

Dose or use Press firmly 2–3 minutes on the inner wrist (two finger-widths below the wrist crease, between the tendons), both sides, 1–2x daily.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceCenturies of traditional use · Human evidence not yet assessedTime to resultsMay offer comfort within minutes; ongoing use for broader benefitTraditional useLong-standing traditional staple
Caution: Check with your healthcare provider before starting, especially if you are pregnant or breastfeeding, take prescription medication, or manage a chronic condition.

What kind of help sounds most like you?

I'd rather use soothing herbs that coat and calm my stomach

Natural remedy

DGL Licorice

Evidence grade B · Traditional use recognised

RCT evidence for easing heartburn

Why it may be relevant

For post-meal burning, deglycyrrhizinated licorice (DGL) may support the protective mucus that coats the stomach and esophageal lining. In a randomized trial, a standardized DGL extract eased heartburn faster than placebo.

A double-blind, placebo-controlled trial found a standardized deglycyrrhizinated licorice extract improved heartburn, regurgitation, and quality of life; the 'DGL' form is chosen to avoid the blood-pressure and potassium effects of whole licorice.

Dose or use Follow product labeling; DGL is often taken as a chewable tablet before or between meals. Consult a healthcare practitioner.

Key study Randomized, double-blind, placebo-controlled Phase III trial (2025, PMID 39929150): a standardized deglycyrrhizinated licorice extract (GutGard) produced earlier resolution of heartburn (p=0.005 at day 28) and regurgitation versus placebo in 200 adults with reflux symptoms.

EvidenceSupported by smaller clinical studies · Recognised traditional useTime to resultsTypically 2-4 weeksTraditional useRecognised traditional use
Caution: Choose the deglycyrrhizinated (DGL) form to avoid the blood-pressure and potassium effects of whole licorice; consult your doctor if pregnant or on medications.
Read the evidence →

Natural remedy

Ginger

Evidence grade C · No traditional record

Trial data in functional dyspepsia

Why it may be relevant

When heartburn follows meals, ginger may support healthy gastric motility; a trial in functional dyspepsia found a steamed ginger extract improved digestive symptoms, including a reflux subscore.

Traditionally used to ease nausea and stomach upset, ginger also improved reflux and indigestion scores in a randomized trial of people with functional dyspepsia - promising, though not a direct heartburn study.

Dose or use Commonly taken as a standardized extract or with food; follow product labeling and consult a healthcare practitioner.

Key study Randomized, double-blind, placebo-controlled trial (2025, PMID 40878144): a steamed ginger extract improved overall GI symptom scores, including the reflux and indigestion subscores, versus placebo in 80 adults with functional dyspepsia (not GERD-specific).

EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 2–4 weeks
Caution: High doses may worsen reflux in some people; consult a doctor if on blood thinners.
Read the evidence →

Natural remedy

Aloe Vera Juice

Evidence grade not assigned · No traditional record

Traditionally used to soothe the digestive tract

Why it may be relevant

For post-meal burning, aloe vera juice is traditionally used to help coat and soothe the esophagus and stomach lining.

Traditionally used for its soothing, anti-inflammatory properties along the digestive tract to ease irritation.

Dose or use Follow product labeling; consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 2–4 weeks
Caution: Use decolorized, purified aloe vera juice; avoid if pregnant or on diabetes or diuretic medications.
Read the evidence →

Natural remedy

Chamomile

Evidence grade not assigned · Traditional use recognised

Traditionally calms both nerves and digestion

Why it may be relevant

When stress sets off your heartburn, chamomile is traditionally used for its calming effect while also soothing an unsettled stomach.

Traditionally used to ease tension and relax the digestive tract, addressing both the stress and the stomach side of stress-driven heartburn.

Dose or use Follow product labeling; commonly taken as a tea after meals or in the evening. Consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 2-4 weeksTraditional useRecognised traditional use
Caution: Avoid if allergic to ragweed, daisies, or related plants; may interact with blood thinners and sedatives.
Read the evidence →

Natural remedy

Slippery Elm (Ulmus rubra)

Evidence grade not assigned · Traditional use recognised

Traditionally used to coat and soothe the gut

Why it may be relevant

When burning follows meals, slippery elm is traditionally used because its mucilage forms a slick coating that can soothe an irritated esophagus and stomach.

Traditionally used as a demulcent: its mucilage coats the digestive tract and may help shield irritated tissue from acid.

Dose or use Follow product labeling; often taken as a powder mixed with water or as capsules/lozenges after meals. Consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 2-4 weeksTraditional useRecognised traditional use
Caution: Its coating action can slow absorption of other medicines - take it a couple of hours apart from prescriptions; consult your doctor if pregnant.
Read the evidence →

What kind of help sounds most like you?

I'm in it for the long game — gut balance, nutrients, and better nights

Natural remedy

Melatonin

Evidence grade C · No traditional record

Trial evidence as a nighttime add-on

Why it may be relevant

For heartburn that worsens when you lie down, melatonin may help support the lower esophageal sphincter and protect the esophageal lining overnight; a small trial tested it added to standard acid-reducing treatment.

Best known for supporting sleep, melatonin was tested as an add-on to omeprazole in one randomized trial and modestly improved heartburn; it has not been shown to work on its own and the finding needs confirmation.

Dose or use Commonly taken as about 3 mg at bedtime in studies; follow product labeling and consult a healthcare practitioner.

Key study Randomized, double-blind trial (2023, PMID 37768310): sublingual melatonin 3 mg added to omeprazole significantly reduced heartburn and reflux symptom scores versus omeprazole plus placebo in 72 adults with GERD; melatonin was not tested on its own.

EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 2–4 weeks
Caution: May cause drowsiness; consult a doctor if on blood thinners or immunosuppressants.
Read the evidence →

Natural remedy

Probiotics (Lactobacillus plantarum P8)

Evidence grade C · No traditional record

Early trial evidence as an add-on therapy

Why it may be relevant

For ongoing, persistent heartburn, rebalancing the gut microbiome may help address an underlying driver of chronic reflux.

One recent trial suggests this strain, taken alongside standard reflux treatment, may help sustain symptom relief. It has not been shown to work on its own, and the finding awaits confirmation in further studies.

Dose or use Follow product labeling; consult a healthcare practitioner.

Key study Single RCT (2026, PMID 41609355) of adjunctive (add-on) probiotic therapy alongside standard GERD treatment; the strain was not tested by itself, and results have not yet been replicated.

EvidenceLimited human trials so far · Most of the research is laboratory or animal workTime to resultsTypically 4–8 weeks
Caution: Consult your doctor if immunocompromised before starting probiotics.
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Natural remedy

Magnesium

Evidence grade not assigned · No traditional record

Low levels may affect muscle and digestive tone

Why it may be relevant

If you're dealing with persistent heartburn, checking whether you're low in magnesium is worthwhile — correcting a deficiency may support healthy muscle tone in the digestive tract.

Magnesium plays a role in smooth muscle relaxation; if you're low, correcting it may help support normal lower esophageal sphincter function.

Dose or use Follow product labeling; consult a healthcare practitioner.

Key study Traditionally used for this condition; this specific use has not been confirmed in controlled clinical trials.

EvidenceNot yet assessed · We have not reviewed the literature for this oneTime to resultsTypically 4–8 weeks
Caution: Consult a doctor if you have kidney disease; high doses can cause loose stools.
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Evidence grades describe the strength of published research for Heartburn, not a promise of results. A higher grade is not a personal recommendation. Nothing here is medical advice — talk to your clinician before starting anything, especially alongside prescription medication.

The evidence behind Heartburn, in one page

We track 11 natural options for Heartburn — what each is typically used for, usual dose, cautions, and the study behind the ones with real trial data.

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Reviewed by the HealisticMD editorial team How we grade evidence →