Unseiin-to is a 12-herb Kampo formula derived from the classical Chinese text 'Jinkui Yaolue' (circa 200 CE) and formally integrated into Japanese Kampo medicine. It is one of the most widely prescribed Kampo formulas in Japan for gynecological conditions and is available as a standardized extract (TJ-106) approved by Japan's Ministry of Health. The formula is designed for women who tend to run cold, have irregular or scanty periods, and experience lower abdominal discomfort.

The formula works through a combination of warming herbs (Evodia, Cinnamon) that improve blood circulation and reduce uterine cold, alongside blood-nourishing herbs (Angelica, Peony, Donkey-hide gelatin) that support adequate menstrual flow and hormonal balance. Anti-inflammatory and circulation-enhancing herbs like Moutan bark and Ligusticum help ease cramping and stagnation. Together, the formula is thought to gently regulate the hypothalamic-pituitary-ovarian axis and improve uterine blood flow.

In Japan, the standardized granule extract (TJ-106 by Tsumura) is the most commonly used form and is the version studied in most clinical trials. Traditional decoctions brewed from raw herbs are used by some Kampo practitioners for individualized care. Tablets and capsules are less common but are available through specialty suppliers in other countries.

• Irregular or absent periods
• Painful periods (dysmenorrhea)
• Cold hands and feet (cold constitution)
• Fertility challenges in women
• Menopausal symptoms
• PMS and premenstrual discomfort
• Uterine fibroids (symptom management)
• Dry skin and chapping with menstrual issues
• Functional infertility (ovulatory support)

• Recurrence of menstrual irregularity after restoration of normal cycles (as a maintenance strategy in Kampo practice)

• Lamb and warming broths — Kampo dietary guidance for Unseiin-to-type constitutions emphasizes warming, blood-nourishing foods; lamb is one of the most traditionally recommended proteins for warming the uterus and replenishing blood.
• Black sesame seeds — Rich in iron and healthy fats, black sesame is a traditional blood-nourishing food in East Asian medicine that mirrors the nourishing function of Angelica and Donkey-hide gelatin in the formula.
• Cinnamon (in food and tea) — One of the formula's key warming herbs; adding cinnamon to meals or tea supports the same warming, circulation-enhancing pathway the formula targets.
• Ginger (fresh, cooked) — Fresh ginger is literally one of the 12 ingredients in Unseiin-to; eating it regularly supports warming digestion and peripheral circulation consistent with the formula's goals.
• Dark leafy greens and liver (iron-rich foods) — Iron-rich foods support healthy blood production, complementing the blood-nourishing herbs in the formula and addressing the underlying deficiency patterns it targets.

• Nausea or stomach upset, especially when taken on an empty stomach
• Diarrhea or loose stools in sensitive individuals
• Skin rash or itching (allergic reaction — discontinue if this occurs)
• Fluid retention or elevated blood pressure with very long-term use (linked to licorice content)
• Low potassium (hypokalemia) with prolonged high-dose use — monitor with long-term treatment
• Feeling of increased warmth or flushing in some women

• Recommended daily: Standard dose: 7.5 g/day of the standardized granule extract (TJ-106), typically divided into 2–3 doses. This corresponds to the conventional Kampo prescription dose used in Japanese clinical practice.
• Best time of day: Traditionally taken before meals or between meals (not immediately after eating) to optimize absorption — typically before breakfast, before dinner, and optionally before lunch.
• With or without food: Take on an empty stomach or 30 minutes before meals when possible; if nausea occurs, taking with a small amount of warm water after food is acceptable.
• Time to effect: Menstrual cycle changes typically noticed within 1–3 cycles (1–3 months); warm-constitution symptoms may improve within 2–4 weeks.
• How long to take it: Typically used for 3–6 months as a course of treatment for menstrual and fertility issues. Reassess with a Kampo practitioner every 1–3 months. Long-term use beyond 6 months should be monitored for licorice-related side effects.