Acne
A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris
https://pubmed.ncbi.nlm.nih.gov/28369875/
Aqueous extract of dried fruit of Berberis vulgaris L. in acne vulgaris, a clinical trial
https://pubmed.ncbi.nlm.nih.gov/23038982/
Effects of fish oil supplementation on inflammatory acne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543297/
Effects of Lactoferrin on Subjective Skin Conditions in Winter: A Preliminary, Randomized, Double-Blinded, Placebo-Controlled Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896904/
Effects of Oral Zinc Gluconate Among Acne Vulgaris Patients
https://clinicaltrials.gov/ct2/show/NCT05096312
Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740760/
New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders
https://pubmed.ncbi.nlm.nih.gov/32046246/
Oral Vitamin A for Acne Management: A Possible Substitute for Isotretinoin
https://pubmed.ncbi.nlm.nih.gov/35674761/
Potential of Curcumin in Skin Disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770633/
Vitamin E in dermatology
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976416/
Common Cold
Antiviral potential of garlic ( Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data
https://pubmed.ncbi.nlm.nih.gov/32836826/
Astragalus in the Prevention of Upper Respiratory Tract Infection in Children with Nephrotic Syndrome: Evidence-Based Clinical Practice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638577/
Echinacea for preventing and treating the common cold
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068831/#:~:text=Of%20the%20seven%20treatment%20trials,in%20prevention%20and%20treatment%20trials.
Effects of orally administered lactoferrin and lactoperoxidase on symptoms of the common cold
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124826/
Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review
https://pubmed.ncbi.nlm.nih.gov/33827515/
Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848651/#:~:text=In%20our%20trial%20elderberry%20supplementation,6.88%20days).
Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231123/
Garlic for the common cold
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465033/
Lactoferrin: Cytokine Modulation and Application in Clinical Practice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658270/
Melatonin possesses an anti-influenza potential through its immune modulatory effect
https://www.sciencedirect.com/science/article/pii/S1756464619302452
N-Acetylcysteine: Multiple Clinical Applications
https://www.aafp.org/pubs/afp/issues/2009/0801/p265.html
Phytochemistry, Pharmacology and Clinical Use of
Andrographis paniculata
https://journals.sagepub.com/doi/pdf/10.1177/1934578X0700200519
Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537893/
Treatment of Common Cold Patients with the Shi-Cha Capsule: A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Dose-Escalation Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544370/
Vitamin C for preventing and treating the common cold
https://pubmed.ncbi.nlm.nih.gov/23440782/#:~:text=No%20consistent%20effect%20of%20vitamin,no%20effect%20on%20the%20conclusions.
Vitamin C in the Prevention and Treatment of the Common Cold
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124957/
Zinc for the common cold
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457799/
Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418896/#:~:text=On%20average%2C%20the%20three%20zinc,days%20in%20the%20placebo%20groups.
Constipation
A randomized trial of the effects of flaxseed to manage constipation, weight, glycemia, and lipids in constipated patients with type 2 diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944250/
Cascara Sagrada
https://medlineplus.gov/druginfo/natural/773.html
Effectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials
https://www.ncbi.nlm.nih.gov/books/NBK291126/
Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial
https://www.frontiersin.org/articles/10.3389/fmicb.2022.985308/full
Prebiotic Galacto-Oligosaccharides Impact Stool Frequency and Fecal Microbiota in Self-Reported Constipated Adults: A Randomized Clinical Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780623/
The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622669/
The effects of psyllium husk on gut microbiota composition and function in chronically constipated women of reproductive age using 16S rRNA gene sequencing analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221300/
Erectile Dysfunction
A Double-Blind, Randomized, Pilot Dose-Finding Study of Maca Root (L. Meyenii) for the Management of SSRI-Induced Sexual Dysfunction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494062/
Acetyl-L-carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration
https://pubmed.ncbi.nlm.nih.gov/35420721/
Dehydroepiandrosterone
https://www.mountsinai.org/health-library/supplement/dehydroepiandrosterone
Effect of ginger, Paullinia cupana, muira puama and l- citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells
https://pubmed.ncbi.nlm.nih.gov/29551532/
Erectile Dysfunction is helped by Ginkgo Extract with whole leaf
Ginseng for erectile dysfunction
https://doctorherdmanclinic.com/resources/articles/mens-health/erectile-dysfunction-ginkgo-extract-with-whole-leaf/
Scientific and Clinical For By Heather S. Oliff, PhD and Mark Blumenthal Proprietary Botanical Ingredient Pycnogenol
https://www.pycnogenol.com/fileadmin/pdf/ABC_Pycnogenol_Monograph_2019.pdf
Scientific medicine in integrative treatment of erectile dysfunction
https://www.journal-ina.com/article.asp?issn=2394-2916;year=2015;volume=2;issue=1;spage=5;epage=18;aulast=Wendlov
The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis
https://pubmed.ncbi.nlm.nih.gov/30770070/
The role of vitamin D supplementation on erectile function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503426/
Frequent Urination
A green and black tea extract benefits urological health in men with lower urinary tract symptoms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003843/
A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549610/
Overactive Bladder Symptoms Alleviated by Dried Cranberry Powder
https://www.medpagetoday.com/resource-centers/overactive-bladder/overactive-bladder-symptoms-alleviated-dried-cranberry-powder/3104
Headaches
A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
https://www.mdpi.com/2072-6643/14/24/5235
Analgesizing effect of a methyl donor (S-adenosylmethionine) in migraine: an open clinical trial
https://pubmed.ncbi.nlm.nih.gov/3514492/
Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial
https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-022-05637-7#:~:text=Few%20previous%20studies%20showed%20the,of%20migraine%20headaches%20%5B12%5D.
Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551876/
Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551876/
Inflammation
A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146259/
Antioxidant and Anti-Inflammatory Effects of Coenzyme Q10 Supplementation on Infectious Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953254/
Dehydroepiandrosterone in systemic lupus erythematosus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701249/
DHEA Enhances Emotion Regulation Neurocircuits and Modulates Memory for Emotional Stimuli
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717538/
Diet and Asthma: Vitamins and Methyl Donors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904132/
Effect of Carnosine in Experimental Arthritis and on Primary Culture Chondrocytes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739233/
Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368679/
Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial
https://pubmed.ncbi.nlm.nih.gov/26342738/
Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685774/
Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003001/
ESWT and nutraceutical supplementation (Tendisulfur Forte) vs ESWT-only in the treatment of lateral epicondylitis, Achilles tendinopathy, and rotator cuff tendinopathy: a comparative study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538506/
Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888220/
Gynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-κB and STAT3 signaling
ncbi.nlm.nih.gov/pmc/articles/PMC5675642/
N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks)
ncbi.nlm.nih.gov/pmc/articles/PMC8211525/
Properties and Therapeutic Application of Bromelain: A Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529416/
Protective Effects of Gynostemma pentaphyllum (var. Ginpent) against
Lipopolysaccharide-Induced Inflammation and Motor Alteration in Mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865846/
Pyrroloquinoline Quinone Decelerates Rheumatoid Arthritis Progression by Inhibiting Inflammatory Responses and Joint Destruction via Modulating NF-κB and MAPK Pathways
https://pubmed.ncbi.nlm.nih.gov/26319019/
Resveratrol (RV): A pharmacological review and call for further research
https://www.sciencedirect.com/science/article/pii/S0753332221009483
The effect of green coffee extract supplementation on cardio metabolic risk factors: a systematic review and meta-analysis of randomized controlled trials
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271291/
The Effect of Omega-3 Fatty Acids on Rheumatoid Arthritis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362115/
The Effect of Vitamin D Supplementation on Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661491/
The impact of thiamine treatment in the diabetes mellitus
https://www.jocmr.org/index.php/JOCMR/article/view/890
The Relevance of Selenium Status in Rheumatoid Arthritis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601319/
Vitamin E As a Potential Interventional Treatment for Metabolic Syndrome: Evidence from Animal and Human Studies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496953/
Zinc in Infection and Inflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490603/
Pain
A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588316/
Alteration of human pain thresholds by nutritional manipulation and l-tryptophan supplementation
https://www.sciencedirect.com/science/article/abs/pii/0304395982900070
Analgesic effect of vitamin E is mediated by reducing central sensitization in neuropathic pain
https://journals.lww.com/pain/Abstract/2006/05000/Analgesic_effect_of_vitamin_E_is_mediated_by.12.aspx#:~:text=ARTICLES-,Analgesic%20effect%20of%20vitamin%20E%20is%20mediated%20by%20reducing%20central%20sensitization%20in%20neuropathic%20pain,-Kim%2C%20Hee%20Kee
Analgesic effectiveness of D-phenylalanine in chronic pain patients
https://pubmed.ncbi.nlm.nih.gov/3524509/
Clinical trials on pain lowering effect of ginger: A narrative review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754412/
Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea
https://pubmed.ncbi.nlm.nih.gov/19216660/
DLPA: Natural Relief for Chronic Pain
https://www.afpafitness.com/blog/dlpa-natural-relief-for-chronic-pain
Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
https://downloads.hindawi.com/journals/crinm/2018/3901619.pdf
Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-020-02985-6
Effectiveness of crocin of saffron (Crocus sativus L.) against chemotherapy-induced peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial
https://www.sciencedirect.com/science/article/abs/pii/S0378874121007406
Effects of Saffron Extract on Sleep Quality: A Randomized Double-Blind Controlled Clinical Trial
https://www.mdpi.com/2072-6643/13/5/1473
Efficacy and Safety of N-Acetylcysteine for the Management of Chronic Pain in Adults: A Systematic Review and Meta-Analysis
https://academic.oup.com/painmedicine/article/22/12/2896/6131682
Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141601/
Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003001/
Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494084/#
Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119581/
Neuroprotective potential of high-dose biotin
https://www.sciencedirect.com/science/article/abs/pii/S0306987717308435?via%3Dihub
Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain
https://pubmed.ncbi.nlm.nih.gov/16531187/
Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache
https://downloads.hindawi.com/journals/crinm/2018/3901619.pdf
Osteoarthrosis and Pantothenic Acid
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1903266/
Pharmacogenetic guidance: individualized medicine promotes enhanced pain outcomes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743122/
Potentiality and safety assessment of combination therapy with silymarin and celecoxib in osteoarthritis of rat model
https://www.sciencedirect.com/science/article/abs/pii/S2210523913000159
Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study
https://europepmc.org/article/med/2138684
The role of vitamin C in the treatment of pain: new insights
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391567/
Therapeutic role of melatonin in migraine prophylaxis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370052/
To compare the effect of a formulation containing Boswellia Serrata extract
on the Osteoarthritis patients pain alleviation and quality of life
improvement With Placebo and Piroxicam Gel; A Randomized Double blind
trial
https://www.researchgate.net/profile/Amir-Eghbalnejad-Mofrad/publication/339130646_To_compare_the_effect_of_a_formulation_containing_Boswellia_Serrata_extract_on_the_Osteoarthritis_patients'_pain_alleviation_and_quality_of_life_improvement_With_Placebo_and_Piroxicam_Gel_A_Randomized/links/5e3f30d4458515072d8a9a41/To-compare-the-effect-of-a-formulation-containing-Boswellia-Serrata-extract-on-the-Osteoarthritis-patients-pain-alleviation-and-quality-of-life-improvement-With-Placebo-and-Piroxicam-Gel-A-Randomized.pdf
Vitamin D in Pain Management
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666851/
PMS
A placebo-controlled clinical trial of l-tryptophan in premenstrual dysphoria
https://www.sciencedirect.com/science/article/abs/pii/S0006322398000055
A randomized, placebo-controlled trial of Ginkgo biloba L. in treatment of premenstrual syndrome
https://pubmed.ncbi.nlm.nih.gov/19678774/
A randomized, placebo-controlled trial of Ginkgo biloba L. in treatment of premenstrual syndrome
https://pubmed.ncbi.nlm.nih.gov/19678774/
Acute tryptophan depletion aggravates premenstrual syndrome
https://www.sciencedirect.com/science/article/abs/pii/0165032794900590
Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial
https://pubmed.ncbi.nlm.nih.gov/18271889/
Effect of calcium on premenstrual syndrome: A double-blind randomized clinical trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313351/
Efficacy of Chamomile in the Treatment of Premenstrual Syndrome: A Systematic Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970572/
Efficacy of Oral Ginger (Zingiber officinale) for Dysmenorrhea: A Systematic Review and Meta-Analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871956/
Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27878/
Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208934/
Evaluation of the effect of omega-3 fatty acids in the treatment of premenstrual syndrome: "a pilot trial"
https://pubmed.ncbi.nlm.nih.gov/23642943/
Ginkgo is Effective for Relief of PMS Symptoms
https://www.naturalmedicinejournal.com/journal/ginkgo-effective-relief-pms-symptoms
Saffron for the Management of Premenstrual Dysphoric Disorder: A Randomized Controlled Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792881/
Systematic Review of Premenstrual, Postmenstrual and Infertility Disorders of Vitex Agnus Castus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308513/
The Effects of Vitamin B1 on Ameliorating the Premenstrual Syndrome Symptoms
ncbi.nlm.nih.gov/pmc/articles/PMC4825494/
The efficacy of Hypericum perforatum (St John's wort) for the treatment of premenstrual syndrome: a randomized, double-blind, placebo-controlled trial
https://pubmed.ncbi.nlm.nih.gov/20155996//
Sleep
A Patient Developed Painful Muscle Cramps due to Overeating Mangos
https://www.hindawi.com/journals/crinm/2012/742125/
A pilot study on essential oil aroma stimulation for enhancing slow-wave EEG in sleeping brain
https://www.nature.com/articles/s41598-020-80171-x
A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/
A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (HolixerTM) on stress, mood, and sleep in adults experiencing stress
https://www.frontiersin.org/articles/10.3389/fnut.2022.965130/full
A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and At-Risk Individuals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524226/
Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double-blind, placebo-controlled clinical trial of efficacy and safety: Aloysia citriodora for insomnia patients: A clinical trial
https://www.researchgate.net/publication/329040000_Aloysia_citriodora_Palau_lemon_verbena_for_insomnia_patients_A_randomized_double-blind_placebo-controlled_clinical_trial_of_efficacy_and_safety_Aloysia_citriodora_for_insomnia_patients_A_clinical_tria
An Updated Review on the Psychoactive, Toxic and Anticancer
Properties of Kava
https://www.mdpi.com/2077-0383/11/14/4039/pdf
Anti-Stress Effects of Lemon Balm-Containing Foods
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245564/
Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747367/
California Poppy and Passion Flower for Sleep
https://www.metagenicsinstitute.com.au/tech-data/california-poppy-passionflower-sleep
Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study
https://pubmed.ncbi.nlm.nih.gov/32818573/#:~:text=Conclusion%3A%20The%20present%20study%20confirms,their%20health%20condition%20and%20age.
Clinical study showing the effects of Lavender ingestible on sleep time
https://books.google.com/books?id=-nvGBAAAQBAJ&pg=PA175&lpg=PA175&dq=clinical+study+showing+the+effects+of+Lavender+ingestible+on+sleep+time&source=bl&ots=NJVqfrfQhg&sig=ACfU3U1qP59U2BzlXUUf8OOi2x4Qs6XXtg&hl=en&sa=X&ved=2ahUKEwjVwJn_5MX8AhUfK0QIHTjuAu84FBDoAXoECAIQAw#v=onepage&q=clinical%20study%20showing%20the%20effects%20of%20Lavender%20ingestible%20on%20sleep%20time&f=false
Clinically proven natural alternatives for treating insomnia
https://www.migrelief.com/wp-content/uploads/2020/09/Sleep_Natural-Alternatives-for-Treating-Insomnia.pdf
Dietary Zinc Acts as a Sleep Modulator
https://www.mdpi.com/1422-0067/18/11/2334
Effect of a medicinal plant (Passiflora incarnata L) on sleep
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699852/
Effect of Inhaled Lavender and Sleep Hygiene on Self-Reported Sleep Issues: A Randomized Controlled Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505755/
Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats
https://pubmed.ncbi.nlm.nih.gov/15700178/
Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827862/
Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002587
Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysi
https://www.sciencedirect.com/science/article/pii/S0149763422002123
Evaluation of the Sleep-Prolonging Effect of Lagenaria vulgaris and Cucurbita pepo Extracts on Pentobarbital-Induced Sleep and Possible Mechanisms of Action
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174352/
GABA and l-theanine mixture decreases sleep latency and improves NREM sleep
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/
Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep
Lavender Fragrance Essential Oil and the Quality of Sleep in Postpartum Women
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914492/
Low-dose niacin supplementation modulates GPR109A, niacin index and ameliorates Parkinsons disease symptoms without side effects
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527813/
Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α
https://pubmed.ncbi.nlm.nih.gov/24077207/
Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063773#:~:text=Melatonin%20also%20significantly%20increased%20total,2.48%2C%20p%20%3D%200.013).
Night Pain Vital Functions (Sleep & Pain) Interact: Use of a California poppy agent to improve restorative sleep
https://www.multibriefs.com/briefs/icim/poppy.pdf
Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-021-03297-z
Passiflora incarnata in Neuropsychiatric DisordersA Systematic Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766837/
Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: A randomized placebo-controlled pilot study
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-11-78?crsi=662497094&cicada_org_src=healthwebmagazine.com&cicada_org_mdm=direct
The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial
https://www.researchgate.net/publication/249321801_The_effect_of_magnesium_supplementation_on_primary_insomnia_in_elderly_A_double-blind_placebo-controlled_clinical_trial
The Effect of Melatonin, Magnesium, and Zinc on Primary Insomnia in Long-Term Care Facility Residents in Italy: A Double-Blind, Placebo-Controlled Clinical Trial
https://agsjournals.onlinelibrary.wiley.com/doi/abs/10.1111/j.1532-5415.2010.03232.x
The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273450/
The effects of light exposure on crewmember fatigue and jetlag: to improve
transportation safety and productivity
https://www.icas.org/ICAS_ARCHIVE/ICAS2010/PAPERS/567.PDF
The Effects of Valerian on Sleep Quality, Depression, and State Anxiety in Hemodialysis Patients: A Randomized, Double-blind, Crossover Clinical Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077445//
The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm
https://pubmed.ncbi.nlm.nih.gov/22849837/#:~:text=Conclusion%3A%20The%20concentration%20of%202,an%20aid%20to%20nocturnal%20sleep.
Valerian Root in Treating Sleep Problems and Associated DisordersA Systematic Review and Meta-Analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585905/
Vitamin D and Its Potential Interplay With Pain Signaling Pathways
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270292/
What is the role of magnesium for skeletal muscle cramps? A Cochrane Review summary with commentary
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020016/#:~:text=From%20a%20functional%20perspective%2C%20experimental,treating%20muscle%20cramps%20remains%20unclear.
WHO technical meeting on sleep and health
https://www.euro.who.int/__data/assets/pdf_file/0008/114101/E84683.pdf
Stress
A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (HolixerTM) on stress, mood, and sleep in adults experiencing stress
https://www.researchgate.net/publication/363227326_A_randomized_double-blind_placebo-controlled_trial_investigating_the_effects_of_an_Ocimum_tenuiflorum_Holy_Basil_extract_HolixerTM_on_stress_mood_and_sleep_in_adults_experiencing_stress
An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750292/
Anti-Stress Effects of Lemon Balm-Containing Foods
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245564/
Association of Use of Omega-3 Polyunsaturated Fatty Acids With Changes in Severity of Anxiety Symptoms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324500/
B Vitamins and the Brain: Mechanisms, Dose and EfficacyA Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/
Calcium antagonists: current and future applications based on new evidence. Effects of calcium channel blockers on oxidative stress
https://europepmc.org/article/med/20048432
Cardiovascular reactivity, stress, and physical activity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819592/
Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey
https://pubmed.ncbi.nlm.nih.gov/33848753/
Effect of Korean Red Ginseng in individuals exposed to high stress levels: a 6-week, double-blind, randomized, placebo-controlled trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606819/
Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153866/
Effects of Adaptogens on the Central Nervous System and the Molecular
Mechanisms Associated with Their StressProtective Activity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991026/
Effects of chromium supplementation on oxidative Stress biomarkers
https://econtent.hogrefe.com/doi/full/10.1024/0300-9831/a000706
Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885294/
Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836118/
Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703329/
Melatonin and the reduction or alleviation of stress
https://pubmed.ncbi.nlm.nih.gov/10496143/
Reducing occupational stress with a B-vitamin focussed intervention: a randomized clinical trial: study protocol
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290459/
Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research
https://www.mdpi.com/2673-9879/2/4/37
The Effects of Magnesium Supplementation on Subjective Anxiety and StressA Systematic Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452159/
Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study
https://pubmed.ncbi.nlm.nih.gov/22228617/
Valerian Root in Treating Sleep Problems and Associated DisordersA Systematic Review and Meta-Analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585905/
Workout Boost
Creatine supplementation with specific view to exercise/sports performance: an update
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407788/
DHEA, DHEA-S and cortisol responses to acute exercise in older adults in relation to exercise training status and sex
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592957/
Effect of Branched-Chain Amino Acid Supplementation on Recovery Following Acute Eccentric Exercise
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212987/
Effect of Cs-4® (Cordyceps sinensis) on Exercise Performance in Healthy Older Subjects: A Double-Blind, Placebo-Controlled Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110835/
Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315638/
Effects of Arginine Supplementation on Athletic Performance Based on Energy Metabolism: A Systematic Review and Meta-Analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282262/
Effects of Protein Supplementation on Performance and Recovery in Resistance and Endurance Training
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142015/
Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021834/
Effects of Vitamin D3 Supplementation and Resistance Training on 25-Hydroxyvitamin D Status and Functional Performance of Older Adults: A Randomized Placebo-Controlled Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746949/
Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520936/
L-Carnitine Supplementation in Recovery after Exercise
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872767/
Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810808/
The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: A double-blind, randomised, placebo-controlled study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291581/
The Effect of Omega-3 Fatty Acid Supplementation on the Inflammatory Response to eccentric strength exercise
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737804/
The Effects of Wild Ginseng Extract on Psychomotor and Neuromuscular Performance Recovery Following Acute Eccentric Exercise: A Preliminary Study
https://www.mdpi.com/2076-3417/10/17/5839
The influence of D-ribose ingestion and fitness level on performance and recovery
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738882/
Vitamin K in sport activities: a less considered benefit for
athletic training
https://jhsrm.org/magazine/010/09-crintea127-132.pdf
Conditions/Topics
Brain Fog
Resveratrol and Brain Fog
Study Name: Resveratrol's Potential Benefits for Brain Fog Relief | Study Source: NeuroLaunch
https://neurolaunch.com/resveratrol-brain-fog/
High blood pressure
Hibiscus Tea for high blood pressure
Effect of hibiscus sabdariffa on blood pressure in patients with stage 1 hypertension
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621350/
Natural Treatments
Semaglutide
Studies Supporting Cardiovascular Benefits
Title of Study: Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
https://www.nejm.org/doi/pdf/10.1056/NEJMoa1607141
Short Description: This pivotal trial investigated the impact of semaglutide on cardiovascular outcomes in type 2 diabetes patients. The study concluded that semaglutide use was associated with a lower incidence of major adverse cardiovascular events.
Studies Supporting Weight Loss
Title of Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2032183?articleTools=true
Short Description: This clinical trial assessed the efficacy of once-weekly semaglutide in adults with overweight or obesity. The findings demonstrated substantial weight loss in participants receiving semaglutide compared to those on placebo.
Title of Study: Semaglutide and Glycemic Control in Type 2 Diabetes
Studies Supporting Type 2 Diabetes Management:
https://www.nejm.org/doi/pdf/10.1056/NEJMoa1607141
Short Description: A New England Journal of Medicine study showed that semaglutide significantly reduced HbA1c and body weight in individuals with type 2 diabetes.
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